Recombinant Human ANXA13, His-tagged

• Cat.No.: ANXA13-26802TH
• Product Overview: Recombinant full length Human Annexin A13 with N terminal His tag; 336 amino acids with tag, Predicted MWt 37.5 kDa.

Specification

• Description: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Protein length: 316 amino acids
• Conjugation: HIS
• Molecular Weight: 37.500kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Gut specific.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMGNRH AKASSPQGFDVDRDAKKLNKACKGM GTNEAAIIEILSGRTSDERQQIKQK YKATYGKELEEVLKSELSGNFEKTA LALLDRPSEYAARQLQKAMKGLGTD ESVLIEVLCTRTNKEIIAIKEAYQR LFDRSLESDVKGDTSGNLKKILVSL LQANRNEGDDVDKDLAGQDAKDLYD AGEGRWGTDELAFNEVLAKRSYKQL RATFQAYQILIGKDIEEAIEEETSG DLQKAYLTLVRCAQDCEDYFAERLY KSMKGAGTDEETLIRIVVTRAEVDL QGIKAKFQEKYQKSLSDMVRSDTSG DFRKLLVALLH
• Sequence Similarities: Belongs to the annexin family.Contains 4 annexin repeats.

Gene Information

• Gene Name: ANXA13 annexin A13 [ Homo sapiens ]
• Official Symbol: ANXA13
• Synonyms: ANXA13; annexin A13; ANX13
• Gene ID: 312
• mRNA Refseq: NM_001003954
• Protein Refseq: NP_001003954
• MIM: 602573
• Uniprot ID: P27216
• Chromosome Location: 8q24.13
• Function: calcium ion binding; calcium-dependent phospholipid binding

Reviews

03/16/2021

Researchers can rely on the ANXA13 protein's specificity and sensitivity to obtain accurate and reliable results.

01/12/2020

the ANXA13 protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.

01/23/2019

The ANXA13 protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.

11/19/2016

In protein electron microscopy structure analysis, the ANXA13 protein demonstrates outstanding performance.

Q&As

Are there any known mutations in the ANXA13 gene that are associated with disease?

Currently, there are no known mutations in the ANXA13 gene that have been directly linked to any specific diseases. However, genetic variations in the ANXA13 gene may exist and could potentially contribute to disease susceptibility or affect ANXA13 function. Further studies are needed to explore the genetic variability of ANXA13 and its potential implications in various diseases.

What cellular compartments or organelles is ANXA13 localized to?

ANXA13, like other annexin proteins, can be found in various cellular compartments or organelles. Annexin proteins have been detected on the plasma membrane, as well as in the cytoplasm, nucleus, mitochondria, endoplasmic reticulum, and lysosomes. The precise subcellular localization of ANXA13 may depend on the specific cell type and experimental conditions.

Are there any diseases associated with ANXA13 mutations or dysregulation?

Mutations in the ANXA13 gene have been associated with certain diseases, such as amyloidosis. Amyloidosis is a disorder characterized by the abnormal accumulation of proteins in various tissues and organs, leading to organ dysfunction. However, research into the specific role of ANXA13 mutations in the development of amyloidosis is still ongoing.

Are there any diseases associated with ANXA13 mutations or dysregulation?

Mutations in the ANXA13 gene have been associated with certain diseases, such as amyloidosis. Amyloidosis is a disorder characterized by the abnormal accumulation of proteins in various tissues and organs, leading to organ dysfunction. However, research into the specific role of ANXA13 mutations in the development of amyloidosis is still ongoing.

Is ANXA13 involved in cancer?

ANXA13 has been implicated in certain cancers. For example, studies have suggested that ANXA13 may promote gastric cancer progression by influencing tumor cell growth and metastasis. However, the exact mechanisms and extent of ANXA13 involvement in cancer development and progression are not fully understood and require further investigation.

Is ANXA13 involved in any physiological processes?

While the specific physiological processes involving ANXA13 are not well defined, annexins, in general, have been implicated in various cellular functions. Annexin proteins are known to be involved in membrane repair, membrane trafficking, regulation of ion channels, cell signaling, and apoptosis. It is possible that ANXA13 may have similar roles, but further research is needed to determine its specific functions.

In which tissues or organs is ANXA13 expressed?

ANXA13 is known to be expressed in various tissues, including the brain, kidney, liver, lung, and pancreas, among others. Its expression pattern may vary depending on the cell type and developmental stage.