Recombinant Human AP1B1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | AP1B1-1261H |
Product Overview : | AP1B1 MS Standard C13 and N15-labeled recombinant protein (NP_001118) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 104.6 kDa |
AA Sequence : | MTDSKYFTTTKKGEIFELKAELNSD KKEKKKEAVKKVIASMTVGKDVSAL FPDVVNCMQTDNLELKKLVYLYLMN YAKSQPDMAIMAVNTFVKDCEDPNP LIRALAVRTMGCIRVDKITEYLCEP LRKCLKDEDPYVRKTAAVCVAKLHD INAQLVEDQGFLDTLKDLISDSNPM VVANAVAALSEIAESHPSSNLLDLN PQSINKLLTALNECTEWGQIFILDC LANYMPKDDREAQSICERVTPRLSH ANSAVVLSAVKVLMKFMEMLSKDLD YYGTLLKKLAPPLVTLLSAEPELQY VALRNINLIVQKRPEILKHEMKVFF VKYNDPIYVKLEKLDIMIRLASQAN IAQVLAELKEYATEVDVDFVRKAVR AIGRCAIKVEQSAERCVSTLLDLIQ TKVNYVVQEAIVVIKDIFRKYPNKY ESVIATLCENLDSLDEPEARAAMIW IVGEYAERIDNADELLESFLEGFHD ESTQVQLQLLTAIVKLFLKKPTETQ ELVQQVLSLATQDSDNPDLRDRGYI YWRLLSTDPVAAKEVVLAEKPLISE ETDLIEPTLLDELICYIGTLASVYH KPPSAFVEGGRGVVHKSLPPRTASS ESAESPETAPTGAPPGEQPDVIPAQ GDLLGDLLNLDLGPPVSGPPLATSS VQMGAVDLLGGGLDSLMGDEPEGIG GTNFVAPPTAAVPANLGAPIGSGLS DLFDLTSGVGTLSGSYVAPKAVWLP AMKAKGLEISGTFTRQVGSISMDLQ LTNKALQVMTDFAIQFNRNSFGLAP AAPLQVHAPLSPNQTVEISLPLSTV GSVMKMEPLNNLQVAVKNNIDVFYF STLYPLHILFVEDGKMDRQMFLATW KDIPNENEAQFQIRDCPLNAEAASS KLQSSNIFTVAKRNVEGQDMLYQSL KLTNGIWVLAELRIQPGNPSCTDLE LSLKCRAPEVSQHVYQAYETILKNT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | AP1B1 adaptor related protein complex 1 subunit beta 1 [ Homo sapiens (human) ] |
Official Symbol : | AP1B1 |
Synonyms : | AP1B1; adaptor-related protein complex 1, beta 1 subunit; ADTB1, CLAPB2; AP-1 complex subunit beta-1; AP105A; BAM22; beta1-adaptin; beta-1-adaptin; beta-adaptin 1; beta-prime-adaptin; Golgi adaptor HA1/AP1 adaptin beta subunit; adaptor protein complex AP-1 subunit beta-1; adapter-related protein complex 1 subunit beta-1; clathrin assembly protein complex 1 beta large chain; plasma membrane adaptor HA2/AP2 adaptor beta subunit; ADTB1; CLAPB2; |
Gene ID : | 162 |
mRNA Refseq : | NM_001127 |
Protein Refseq : | NP_001118 |
MIM : | 600157 |
UniProt ID : | Q10567 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionAP1B1 mutations may be associated with retinal diseases, but there are relatively few studies directly related to vision problems.
Some studies have shown that the AP1B1 gene mutation may be associated with some mental diseases such as schizophrenia.
AP1B1 mutation may affect intracellular vesicle transport and membrane protein localization, thus affecting the efficacy of therapy and the action of drugs.
Some studies have shown that mutations in the AP1B1 gene may be associated with diseases related to intellectual development.
AP1B1 mutations may be associated with a variety of diseases, including congenital retinitis pigmentosa and neurodegenerative diseases.
Gene-editing techniques such as CRISPR-Cas9 could potentially be used to fix AP1B1 mutations, but they are still in the laboratory stage and require further research and trials.
AP1B1 mutation may be hereditary, and the specific inheritance pattern may be related to each specific mutation.
There is currently no specific treatment for diseases caused by AP1B1 mutations, but the quality of life of patients can be improved through symptom relief treatment and rehabilitation training.
AP1B1 plays an important role in cell regulation by participating in intracellular vesicle transport and cell membrane protein localization.
AP1B1 mutation may lead to the abnormality of intracellular signal transduction pathway and affect the normal process of various biochemical reactions in the cell.
There is currently no direct way to prevent AP1B1 mutations, but a healthy lifestyle and genetic counseling may help reduce the risk of certain genetic diseases.
Recent studies have shown that AP1B1 plays an important role in intracellular vesicle transport and neuronal development.
It is unclear whether AP1B1 mutations directly affect longevity.
AP1B1 gene mutation can be detected by molecular biological methods such as gene sequencing.
Customer Reviews (4)
Write a reviewReproducibility of the AP1B1 is very good, which can reduce the error in the experiment and improve the repeatability of the experiment.
AP1B1 labeling effect is very good, can be used for fluorescence labeling, etc., which is very suitable for our research.
It is very stable, even after multiple uses or storage, its structure and function remain stable, providing strong support for long-term experiments and applications.
Catalytic activity of this protein is very strong, which can make chemical reactions that are difficult to carry out easy to achieve, and has high application potential.
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