Recombinant Human AP1S3 Protein (1-104 aa), GST-tagged

• Cat.No.: AP1S3-330H
• Product Overview: Recombinant Human AP1S3 Protein (1-104 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Protein Description: Full Length of Isoform 3.

Specification

• Description: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to mbranes and the recognition of sorting signals within the cytosolic tails of transmbrane cargo molecules. Involved in TLR3 trafficking.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 39.7 kDa
• Protein length: 1-104 aa
• AA Sequence: MIHFILLFSRQGKLRLQKWYITLPD KERKKITREIVQIILSRGHRTSSFV DWKELKLVYKRYASLYFCCAIENQD NELLTLEIVHRYVELLDKYFGNTWP FARA
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: AP1S3 adaptor related protein complex 1 subunit sigma 3 [ Homo sapiens (human) ]
• Official Symbol: AP1S3
• Synonyms: PSORS15
• Gene ID: 130340
• mRNA Refseq: NM_001039569
• Protein Refseq: NP_001034658
• UniProt ID: Q96PC3

Q&As

How is the research progress of AP1S3 ?

The research of AP1S3 is in the continuous development stage. There are some studies on its structure and function, but more clinical and scientific data are needed.

Is AP1S3 gene mutation associated with inherited immune diseases?

Yes, mutations in the AP1S3 gene are associated with certain inherited immune disorders, such as autosomal recessive leukocyte deficiency.

What is the structure and function of AP1S3 ?

The AP1S3 belongs to one of the subunits of the vesicular protein aptamer complex (AP) and is involved in the regulation of material transport in organelles.

What is the source of AP1S3 ?

The AP1S3 is usually prepared in the laboratory through genetic engineering techniques.

What is the prospect of AP1S3 in clinical medicine?

The AP1S3 has great promise in clinical medicine, which can help to understand the mechanism of disease, early diagnosis and individualized treatment.

What can the study of AP1S3 help us learn?

The study of AP1S3 contributes to a deeper understanding of the pathogenesis of related diseases, immune regulation and the development of new drugs.

Does the application of AP1S3 require special experimental conditions?

Studying the application of AP1S3 generally requires special experimental conditions and equipment, which can be carried out in the laboratory.

What are the applications of AP1S3 in drug development?

AP1S3 can be used for target screening, drug effect evaluation and drug safety evaluation in drug development.

Is the AP1S3 associated with genetic diseases?

Yes, the mutation of AP1S3 gene is associated with the occurrence of some genetic diseases, and the mechanism of these genetic diseases can be deeply understood through the study of AP1S3 .

What is the AP1S3 used for?

The AP1S3 is a protein that can be used to investigate clinical or scientific questions related to AP1S3.

What diseases have been studied related to AP1S3 ?

Several studies have shown that the AP1S3 is associated with certain tumors, autoimmune diseases, and neurological disorders.

What is the preparation method of AP1S3 ?

AP1S3 is usually prepared in the expression host through genetic engineering technology, and then obtained through purification, crystallization and other steps.

Can AP1S3 be used to screen drugs?

Yes, the AP1S3 can be used for drug screening and the development of new treatments.

What are the clinical applications of AP1S3 ?

AP1S3 can be used to study the pathogenesis of related diseases, drug screening and clinical diagnosis and treatment monitoring.

Can AP1S3 be used to prepare diagnostic kits?

Yes, the recombinant AP1S3 protein can be used to prepare kits for the diagnosis of related diseases, contributing to early clinical diagnosis and treatment.

What scientific research fields can AP1S3 be used in?

AP1S3 can be applied to cell biology, molecular biology, immunology and other scientific research fields to conduct in-depth research on related diseases.

What is the role of AP1S3 in cancer research?

The AP1S3 contributes to the understanding of tumor cell growth, metastasis and invasion mechanisms in cancer research, and may be a potential drug target for new tumor targeted therapies.

Does AP1S3 have side effects?

The AP1S3 is for laboratory research purposes and no associated side effects have been reported at this time, but more detailed research and evaluation are needed if applied to the clinic.

Is the AP1S3 related to the immune system?

The AP1S3 is closely related to the immune system and can be involved in the regulation of immune cell function and signaling.

What are the potential clinical applications of AP1S3 ?

Potential clinical applications of AP1S3 include early diagnosis, guidance of preventive treatment strategies, and target evaluation of new drug development.