Recombinant Human AP3S2, T7-tagged
Cat.No. : | AP3S2-71H |
Product Overview : | Recombinant Human adaptor-related protein complex 3, sigma 2 subunit produced inE.coliis a non-glycosylated, polypeptide chain containing amino acids (1-193) and having a total molecular mass of 22.2 kDa. rhAP3S2 contains T7 tag at N-terminus and is purified by proprietary chromatographic techniques. |
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Cat. No. : | AP3S2-71H |
Description : | Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. |
Source : | Escherichia coli. |
Physical Appearance : | Sterile Filtered clear solution. |
Purity : | Greater than 95.0% as determined by the analysis by reducing and non-reducing SDS-PAGE coomassie blue staining. |
Formulation : | Recombinant Human AP2M1 at a concentration of 0.1mg/ml containing 10 mM Tris, pH 8.0, 0.01% Triton X-100 and 0.002% NaN3 and 10mM DTT. |
Applications : | • ELISA • MS• Western Blotting. |
Storage : | RhAP3S2 although stable at 14°C for 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | AP3S2 adaptor-related protein complex 3, sigma 2 subunit [ Homo sapiens ] |
Synonyms : | AP3S2; adaptor-related protein complex 3, sigma 2 subunit; AP3S3; sigma3b; FLJ35955; AP-3 complex subunit sigma-2; Adapter-related protein complex 3 sigma-2 subunit; AP-3 complex sigma-3B subunit; Sigma-adaptin 3b; Sigma3B-adaptin; clathrin-associated/assembly/adaptor protein, small 4, 22-kD; adaptor complex sigma3B |
Gene ID : | 10239 |
mRNA Refseq : | NM_005829 |
Protein Refseq : | NP_005820 |
MIM : | 602416 |
UniProt ID : | P59780 |
Chromosome Location : | 15q26.1 |
Pathway : | Lysosome |
Function : | protein binding; protein transporter activity |
Products Types
◆ Recombinant Protein | ||
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AP3S2-193H | Recombinant Human AP3S2 Protein, His-tagged | +Inquiry |
AP3S2-5503C | Recombinant Chicken AP3S2 | +Inquiry |
AP3S2-660H | Recombinant Human AP3S2 protein, GST-tagged | +Inquiry |
AP3S2-350R | Recombinant Rhesus monkey AP3S2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
AP3S2-8807HCL | Recombinant Human AP3S2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (16)
Ask a questionAP3S2 can also be used in the treatment of inflammation, autoimmune diseases and other fields.
The AP3S2 has a relative molecular mass of about 16-18KDa and an isoelectric point of about 5.5-6.0.
The AP3S2 belongs to the small G protein family and has the structure of GTPase activity, which is similar to other small G proteins in terms of molecular structure.
With the continuous research and in-depth understanding of the mechanism of action of AP3S2 , its future treatment prospects in tumor, inflammation and other fields are broad.
At present, there are no reports and studies on the application of AP3S2 in clinical treatment.
At present, the therapeutic value of recombinant AP3S2 protein is mainly concentrated in the fields of tumor and inflammation.
AP3S2 is involved in intracellular protein transport, which can directly affect the growth and proliferation of cancer cells. It can also promote the immune system to clear cancer cells.
The combination of AP3S2 and other therapeutic agents can have a better therapeutic effect, but the specific effect needs to be further studied.
The optimal storage condition of AP3S2 is the refrigerator at -20℃, avoid light and moisturize, and do not repeatedly freeze and thaw.
Recombinant AP3S2 protein is involved in intracellular immune regulation and can affect the tubule system, cytophagocytosis and the formation of acidic lysosomes.
The AP3S2 is involved in protein transport from the Golgi apparatus to the endoplasmic reticulum during intracellular transport.
Recombinant AP3S2 protein in mouse model can significantly promote tumor growth inhibition and reduce tumor metastasis.
The cost of synthesis of AP3S2 varies according to different manufacturers, methods and other factors.
At present, the preclinical research of AP3S2 mainly focuses on in vivo and in vitro experiments and animal model studies.
AP3S2 can be prepared by synthesis, expression and purification.
The preparation difficulty of AP3S2 depends on the specific preparation method and experimental conditions.
Customer Reviews (4)
Write a reviewGreen production process of AP3S2 is very advanced, using the most environmentally friendly production process and is very friendly to the environment.
They have a wide range of products and can always find the AP3S2 we need.
Catalytic activity of AP3S2 is really amazing, and it can bring unexpected catalytic effects every time it is used, and its performance is impressive.
The reproducibility of AP3S2 can be said to be almost 100 percent, and the results are very consistent in every experiment or application, which is an important indication of its excellent quality.
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