Recombinant Human AP4M1 protein, GST-tagged
Cat.No. : | AP4M1-663H |
Product Overview : | Human AP4M1 full-length ORF ( AAH18705, 1 a.a. - 453 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 75.57 kDa |
AA Sequence : | MISQFFILSSKGDPLIYKDFRGDSG GRDVAELFYRKLTGLPGDESPVVMH HHGRHFIHIRHSGLYLVVTTSENVS PFSLLELLSRLATLLGDYCGSLGEG TISRNVALVYELLDEVLDYGYVQTT STEMLRNFIQTEAVVSKPFSLFDLS SVGLFGAETQQSKVAPSSAASRPVL SSRSDQSQKNEVFLDVVERLSVLIA SNGSLLKVDVQGEIRLKSFLPSGSE MRIGLTEEFCVGKSELRGYGPGIRV DEVSFHSSVNLDEFESHRILRLQPP QGELTVMRYQLSDDLPSPLPFRLFP SVQWDRGSGRLQVYLKLRCDLLSKS QALNVRLHLPLPRGVVSLSQELSSP EQKAELAEGALRWDLPRVQGGSQLS GLFQMDVPGPPGPPSHGLSTSASPL GLGPASLSFELPRHTCSGLQVRFLR LAFRPCGNANPHKWVRHLSHSDAYV IRI |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AP4M1 adaptor-related protein complex 4, mu 1 subunit [ Homo sapiens ] |
Official Symbol : | AP4M1 |
Synonyms : | AP4M1; adaptor-related protein complex 4, mu 1 subunit; AP-4 complex subunit mu-1; adaptor related protein complex AP 4 mu4 subunit; AP 4 adapter complex mu subunit; mu subunit of AP 4; MU 4; mu adaptin related protein 2; MU ARP2; mu4; mu4-adaptin; mu subunit of AP-4; mu-adaptin-related protein 2; mu-adaptin-related protein-2; adapter-related protein complex 4 mu-1 subunit; adaptor-related protein complex AP-4 mu4 subunit; MU-4; CPSQ3; MU-ARP2; |
Gene ID : | 9179 |
mRNA Refseq : | NM_004722 |
Protein Refseq : | NP_004713 |
MIM : | 602296 |
UniProt ID : | O00189 |
Products Types
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◆ Lysates | ||
AP4M1-88HCL | Recombinant Human AP4M1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionDelivery systems, such as targeted nanoparticles or viral vectors, can potentially be used to specifically deliver AP4M1 protein to desired tissues or organs.
The structure of AP4M1 protein has been studied using techniques like X-ray crystallography, revealing important insights into its function.
Animal models, such as mice with genetic modifications or knockouts, can help researchers investigate the role and impact of AP4M1 protein in various disease contexts.
It is possible that AP4M1 could be used as a therapeutic agent in the future, but more research is needed.
Various cellular mechanisms, such as transcription factors and signaling pathways, may regulate AP4M1 protein expression.
At the moment, there are no known ongoing clinical trials involving AP4M1 protein, but it is an area of active research.
The possibility of combining AP4M1 protein with other therapeutic agents for synergistic effects could be explored in future studies.
Detecting AP4M1 protein levels or mutations could potentially be used as a diagnostic tool for certain diseases or genetic disorders.
AP4M1 protein may play a role in cancer cell migration and invasion, making it a potential target for cancer therapeutics or biomarkers.
Challenges may include optimizing protein purification methods, ensuring proper folding and functionality, and maintaining stability during production.
Strategies like using blood-brain barrier-penetrating nanoparticles or viral vectors could potentially enable the delivery of AP4M1 protein to the brain for neurological disorders.
Future research may focus on elucidating the molecular mechanisms of AP4M1, exploring its role in different diseases, and developing therapeutic strategies.
Mutations in the AP4M1 gene have been associated with a rare genetic disorder called AP-4 deficiency syndrome.
Currently, there are no known natural compounds that have been identified as direct modulators of AP4M1 protein activity.
AP4M1 is a subunit of the AP-4 complex, which plays a role in protein trafficking within cells.
Understanding the three-dimensional structure of AP4M1 could provide valuable information for designing drugs that specifically target this protein.
Techniques like CRISPR-Cas9 gene editing or siRNA knockdown can be employed to study the cellular effects of AP4M1 protein.
As AP4M1 protein therapy is still in the early stages of research, potential side effects and risks are not yet fully understood and need further investigation.
Yes, AP4M1 has been found to interact with other proteins within the AP-4 complex and in other cellular processes.
Currently, there are no known specific inhibitors or activators of AP4M1 protein, but research is ongoing in this area.
Customer Reviews (3)
Write a reviewThe short half-life and high clearance characteristics of AP4M1 enable it to better control the concentration and duration of action of the drug in the body, so as to better grasp the therapeutic effect.
High band strength of this protein in Western blot improves the signal-to-noise ratio of the experiment.
After a long period of storage or repeated use, the stability of AP4M1 is still very good, indicating its high reliability and trustworthiness.
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