Recombinant Human APC2, His-tagged

• Cat.No.: APC2-3154H
• Product Overview: Adenomatous polyposis coli protein 2 (APC2), partial

Specification

• Source: E. Coli or Yeast
• Species: Human
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 2303
• Purity: >90%
• Notes: Small volumes of APC2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: APC2 adenomatosis polyposis coli 2 [ Homo sapiens ]
• Official Symbol: APC2
• Synonyms: APC2; adenomatosis polyposis coli 2; adenomatous polyposis coli protein 2; adenomatous polyposis coli like; APCL
• Gene ID: 10297
• mRNA Refseq: NM_005883
• Protein Refseq: NP_005874
• MIM: 612034
• UniProt ID: O95996
• Chromosome Location: 19p13.3
• Pathway: Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, cons
• Function: beta-catenin binding; microtubule binding; protein binding

Reviews

07/02/2022

APC2 production process is truly green, environmentally friendly, and has almost no impact on the environment, demonstrating the concept of sustainable development.

04/25/2021

The stability of APC2 is very excellent, and its performance remains stable even after a long period of storage or multiple freeze-thaw cycles, which shows its excellent storage stability.

08/29/2020

Catalytic activity of APC2 is very powerful, and it can successfully complete difficult chemical reactions, and its breakthrough effect is admirable.

01/25/2019

Short half-life and high clearance characteristics of APC2 provide patients with more timely and effective treatment.

01/17/2019

The stability of APC2 is truly amazing, and the performance remains the same even after multiple uses, showing excellent product quality.

Q&As

What is the effect of APC2 on tumor cell proliferation and metastasis?

APC2 is considered to be a tumor suppressor gene, and its deletion or mutation may lead to enhanced proliferation and metastasis of tumor cells.

What are the structural characteristics of APC2?

The structural characteristics of APC2 include multiple functional domains, involvement in signal transduction inside and outside the cell, and interaction with a variety of proteins.

Is there a polymorphic mutation in APC2?

Polymorphic mutations exist in APC2, and the type and location of mutations may vary between individuals.

Is APC2 relevant to tumor immunotherapy?

At present, no relevant studies have shown that APC2 has a direct relationship with tumor immunotherapy.

Can APC2 be used as a tumor marker?

The presence of mutations in APC2 may lead to tumor cell proliferation, but whether it is used as a marker for specific tumors needs further study.

What is the role of APC2 in apoptosis?

APC2 is antitumor by promoting apoptosis.

What is the effect of APC2 on tumor stem cells?

APC2 may play a role in tumor inhibition by inhibiting the proliferation and differentiation of tumor stem cells.

What role does APC2 play in the development of tumor?

APC2 plays a complex regulatory role in tumorigenesis and development, including the regulation of signaling pathways such as Wnt, the influence of cell proliferation and apoptosis, and the regulation of cell cycle. The exact mechanism still needs further study.

What is the relationship between APC2 and tumor prognosis?

Deletion or mutation of APC2 may lead to enhanced proliferation and metastasis of tumor cells, which may adversely affect tumor prognosis.

What is the recent research progress of APC2?

Recent studies have shown that APC2 also plays an important role in aspects such as cell polarity and angiogenesis, and related studies are ongoing.

How does the mutation rate of APC2 differ among different cancers?

The mutation rate of APC2 varies widely among different cancers, such as colon and stomach cancer.

How does APC2 interact with other cytokines?

APC2 can interact with receptors, signal transduction factors and other cytokines, including Wnt, β-catenin, TGF-β and so on.

How is APC2 applied in clinical diagnosis?

APC2 has not yet been used in clinical diagnosis, but with further research, more applications may be possible.

Is APC2 associated with neurodegenerative diseases?

Some studies have suggested that APC2 may be involved in neurodegenerative diseases such as Alzheimer's and Parkinson's, but the specific mechanism needs further study.

How can APC2 be used in drug design?

The study of APC2 can provide references for drug design, such as finding new tumor therapeutic targets and designing new tumor drugs.

What are the expression and purification methods of the full-length of APC2?

The expression and purification methods of the full-length of APC2 include prokaryotic and eukaryotic expression.

Are mutations in the subunits of APC2 substrates associated with certain cancers?

Studies have shown that in patients with colon and stomach cancer, there is a higher probability of mutations in the subunit of APC2 substrate binding.

What is the relationship between APC2 and tumor pharmacology?

The study of APC2 is of great significance for the development of tumor pharmacology and can provide reference for finding new anticancer therapeutic targets.

What is the relationship between the structure and function of APC2?

There is a close relationship between the structure and function of APC2, and its different domains and functional areas can be involved in different cellular signal transduction and regulation processes.

What is the pro-apoptotic mechanism of APC2 on tumor cells?

APC2 can play a role in promoting apoptosis by activating the apoptosis pathway in tumor cells, such as activating caspase.