Recombinant Human APEH protein, GST-tagged

• Cat.No.: APEH-676H
• Product Overview: Human APEH full-length ORF ( NP_001631.3, 1 a.a. - 732 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 107.6 kDa
• AA Sequence: MERQVLLSEPEEAAALYRGLSRQPA LSAACLGPEVTTQYGGQYRTVHTEW TQRDLERMENIRFCRQYLVFHDGDS VVFAGPAGNSVETRGELLSRESPSG TMKAVLRKAGGTGPGEEKQFLEVWE KNRKLKSFNLSALEKHGPVYEDDCF GCLSWSHSETHLLYVAEKKRPKAES FFQTKALDVSASDDEIARLKKPDQA IKGDQFVFYEDWGENMVSKSIPVLC VLDVESGNISVLEGVPENVSPGQAF WAPGDAGVVFVGWWHEPFRLGIRFC TNRRSALYYVDLIGGKCELLSDDSL AVSSPRLSPDQCRIVYLQYPSLIPH HQCSQLCLYDWYTKVTSVVVDVVPR QLGENFSGIYCSLLPLGCWSADSQR VVFDSAQRSRQDLFAVDTQVGTVTS LTAGGSGGSWKLLTIDQDLMVAQFS TPSLPPTLKVGFLPSAGKEQSVLWV SLEEAEPIPDIHWGIRVLQPPPEQE NVQYAGLDFEAILLQPGSPPDKTQV PMVVMPHGGPHSSFVTAWMLFPAML CKMGFAVLLVNYRGSTGFGQDSILS LPGNVGHQDVKDVQFAVEQVLQEEH FDASHVALMGGSHGGFISCHLIGQY PETYRACVARNPVINIASMLGSTDI PDWCVVEAGFPFSSDCLPDLSVWAE MLDKSPIRYIPQVKTPLLLMLGQED RRVPFKQGMEYYRALKTRNVPVRLL LYPKSTHALSEVEVESDSFMNAVLW LRTHLGS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: APEH N-acylaminoacyl-peptide hydrolase [ Homo sapiens ]
• Official Symbol: APEH
• Synonyms: APEH; N-acylaminoacyl-peptide hydrolase; D3F15S2, D3S48E, DNF15S2; acylamino-acid-releasing enzyme; acyl-peptide hydrolase; acylaminoacyl-peptidase; oxidized protein hydrolase; APH; OPH; AARE; ACPH; D3S48E; D3F15S2; DNF15S2; MGC2178
• Gene ID: 327
• mRNA Refseq: NM_001640
• Protein Refseq: NP_001631
• MIM: 102645
• UniProt ID: P13798

Reviews

05/09/2022

The green production process of APEH is very advanced and adopts the most environmentally friendly production technology, which is worthy of vigorous promotion.

02/28/2022

High clearance of APEH demonstrated its excellent pharmacokinetic characteristics and provided a new direction for biomedical research.

03/11/2021

Clear banding and no impurity interference, showing its excellent purity and specificity.

06/09/2019

Can maintain consistent performance every time it is used, which provides great convenience for experiments.

Q&As

What are the side effects of APEH ?

At present, the side effects of APEH are relatively limited, and further clinical and scientific studies are needed to evaluate them.

What is APEH ?

APEH is a protein prepared by recombinant technology of human amino terminal hydrolase (APEH) gene.

What is the application of APEH in the treatment of neurological diseases?

APEH may be used to treat nervous system diseases by regulating neuronal function and alleviating nervous system inflammation.

What is the safety and efficacy of APEH in clinical trials?

At present, there are few clinical trial studies on APEH , and more data are needed to evaluate its safety and efficacy.

What is the relationship between APEH and tumor therapy?

The APEH may affect the genesis and development of tumor by regulating the expression of tumor-related genes.

What is the preparation method of APEH ?

The preparation of APEH is mainly accomplished through the steps of gene cloning, expression and purification.

What is the latest progress of APEH in preclinical research?

The latest research indicates that the APEH may have potential application value in the treatment of tumor and nervous system diseases.

What are the biological functions of APEH ?

APEH can participate in the biological processes of protein catabolism and amino acid release.

In what scientific research fields is APEH widely studied?

The of APEH has been studied in biochemistry, molecular biology, pharmacology and other fields.

What is the clinical value of APEH ?

APEH has potential clinical application value, and may play a role in the treatment of tumor and nervous system diseases.