Recombinant Human APEX Nuclease 1
Cat.No. : | APEX1-593H |
Product Overview : | Recombinant human APEX1 protein produced inE. coli,36kDa. |
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Cat. No. : | APEX1-593H |
Description : | Apurinic/apyrimidinic (AP) sites (also called "abasic sites") occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication. All cells, from simple prokaryotes to humans, have evolved systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5" to the AP site, thereby initiating a process known as base excision repair (BER). The APEX gene (alternatively named APE1, HAP1, APEN) encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. |
Source : | E. coli. |
Concentration : | 1 mg/ml. |
Purity : | ≥95% (SDS-PAGE). |
Formulation : | Liquid. In 20mM HEPES-KOH, pH 7.5, containing 100mM NaCl and 20% glycerol. |
Storage : | Enzyme is stable for ~2 weeks at -20°C. After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. |
Pathways : | Base excision repair; DNA Repair |
Gene Name : | APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 [ Homo sapiens ] |
Synonyms : | APEX nuclease (multifunctional DNA repair enzyme) 1; APE; APX; APE1; APEN; APEX; HAP1; REF1; APEX1; DNA-(apurinic or apyrimidinic site) lyase; AP lyase; protein REF-1; redox factor 1; AP endonuclease 1; AP endonuclease class I; apurinic/apyrimidinic exonuclease; multifunctional DNA repair enzyme; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic (abasic) endonuclease; deoxyribonuclease (apurinic or apyrimidinic); EC 4.2.99.18; APEX nuclease (multifunctional DNA repair enzyme);APE-1; REF-1; APEX nuclease 1; APEX nuclease |
Gene ID : | 328 |
mRNA Refseq : | NM_001641 |
Protein Refseq : | NP_001632 |
MIM : | 107748 |
UniProt ID : | P27695 |
Chromosome Location : | 14q11.2-q12 |
Function : | 3"-5" exonuclease activity; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; endodeoxyribonuclease activity; endonuclease activity; lyase activity; metal ion binding; oxidoreductase activity; phosphodiesterase I activity; phosphoric diester hydrolase activity; protein binding; ribonuclease H activity; transcription coactivator activity; transcription corepressor activity; uracil DNA N-glycosylase activity |
Products Types
◆ Recombinant Protein | ||
APEX1-182R | Recombinant Rhesus Macaque APEX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
APEX1-2497H | Recombinant Human APEX1 protein(Pro2-Leu318), His-tagged | +Inquiry |
APEX1-1330H | Recombinant Human APEX1 Protein (32-318 aa), His-tagged | +Inquiry |
Apex1-623M | Recombinant Mouse Apex1 Protein, MYC/DDK-tagged | +Inquiry |
APEX1-354H | Recombinant Human APEX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
APEX1-8797HCL | Recombinant Human APEX1 293 Cell Lysate | +Inquiry |
APEX1-8796HCL | Recombinant Human APEX1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionThe recombinant APEX1 protein may have broader application prospects in future clinical applications, especially in the treatment of diseases related to DNA damage.
The recombinant APEX1 protein can be used in scientific research to study the DNA repair pathway and the pathogenesis of related diseases.
The APEX1 is a DNA repair enzyme that can repair DNA bases damaged by oxidation.
The recombinant APEX1 protein can perform biological functions in the body and participate in the repair process of DNA.
In general, there are no serious side effects from the use of APEX1 , but specific side effects need to be evaluated based on actual use.
Yes, the recombinant APEX1 protein has antioxidant effects and can help reduce the damage to cells caused by oxidative stress.
APEX1 is not currently widely used in gene therapy, but it may have potential applications in related studies.
Yes, some studies have shown that the APEX1 can improve the occurrence and development of cardiovascular disease.
The study and detection of APEX1 can be performed using conventional immunological and biochemical methods.
The synthesis methods of APEX1 mainly include prokaryotic expression system and eukaryotic expression system.
The antioxidant and DNA repair effects of APEX1 make it a potential candidate molecule for anticancer drugs.
Yes, some studies have shown that the presence of recombinant APEX1 protein can improve the efficiency of DNA repair.
The therapeutic effect of APEX1 can be evaluated through cell experiments, animal experiments and clinical trials.
Purified samples of APEX1 can be obtained by protein expression and purification techniques.
APEX1 can be used clinically to treat diseases related to DNA damage, such as cancer.
The APEX1 is relevant for the treatment of diseases related to DNA damage such as cancer and neurological diseases.
No studies have shown that recombinant APEX1 can extend life span.
When using APEX1 , it is necessary to pay attention to the appropriate dosage and method, and follow the relevant experimental procedures.
There are currently no commercially available APEX1 drugs, but research is ongoing.
Yes, the recombinant APEX1 protein is associated with cancer because its abnormal function in DNA damage repair can lead to the development of cancer.
Customer Reviews (5)
Write a reviewHigh clearance of APELA allow the drug to act more quickly and reach the therapeutic goal quickly.
Zero pollution in the production process has a positive impact on the environment.
Easy to use, good results, great results.
The sensitivity of APELA in Western blot is very high, and clear bands can be obtained even at low concentrations, indicating that it has the characteristics of high sensitivity and low background noise.
It still maintains stable performance after a long time of use, showing excellent product quality.
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