Recombinant Human ApoE2
Cat.No. : | ApoE2-3561H |
Product Overview : | ApoE2 |
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Description : | Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. |
Source : | E. Coli |
Species : | Human |
Form : | Lyophilized |
Molecular Mass : | 36,154 Da |
Protein length : | 317 |
Purity : | >90% by SDS-PAGE & HPLC analyses |
Notes : | Small volumes of ApoE2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | ApoE2 |
Official Symbol : | ApoE2 |
Synonyms : | APOE; APOE; AD2; LPG; LDLCQ5; Apo-E; |
Gene ID : | 348 |
mRNA Refseq : | NM_000041.2 |
Protein Refseq : | NP_000032.1 |
MIM : | 104310 |
UniProt ID : | P02649 |
Chromosome Location : | Chromosome: 19; NC_000019.10 (44905782..44909393). Location: 19q13.2 |
Function : | ?ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants |
Products Types
◆ Recombinant Protein | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (24)
Ask a questionThe ApoE2 protein has been studied as a potential therapeutic target for Alzheimer's disease. Its association with a reduced risk of developing the disease has sparked interest in understanding its mechanisms and potential protective effects. However, more research is needed to fully understand its role and whether it can be effectively targeted for therapeutic interventions.
Lifestyle factors, such as exercise and diet, can potentially interact with the ApoE2 allele and influence health outcomes. Regular exercise and a healthy diet have been associated with improved cardiovascular and cognitive health in individuals with the ApoE2 allele, potentially enhancing its protective effects. However, more research is needed to fully understand these interactions.
The presence of the ApoE2 allele appears to influence the metabolism of amyloid beta protein, which is a key component of the plaques found in the brains of Alzheimer's disease patients. ApoE2 has been suggested to exhibit a more efficient clearance of amyloid beta, potentially reducing its accumulation and mitigating the development of the disease.
While the ApoE2 allele is primarily associated with a reduced risk of Alzheimer's disease, there is limited evidence suggesting that it may also have subtle effects on cognition and brain function in individuals without the disease. Further research is needed to fully understand the impact of the ApoE2 allele on cognitive abilities in non-Alzheimer's populations.
Yes, lifestyle factors can still play a significant role in the impact of the ApoE2 protein. Adopting a healthy lifestyle with regular exercise, a balanced diet, and overall good cardiovascular health can help mitigate potential risks and optimize health outcomes.
The unique properties of the ApoE2 protein have prompted research into utilizing it for potential therapeutic interventions. Strategies aimed at promoting its beneficial effects or mimicking its actions are being investigated, but any such therapies are currently in the experimental stage and not yet available for clinical use.
While there are no specific dietary recommendations exclusively for individuals with the ApoE2 allele, a healthy diet is generally recommended for everyone. This includes consuming a variety of nutrient-rich foods, such as fruits, vegetables, whole grains, lean proteins, and healthy fats. It is also important to limit the intake of processed foods, saturated fats, trans fats, and added sugars.
The ApoE2 protein itself is not typically targeted for therapeutic interventions to increase its expression. However, research is ongoing to develop interventions that can enhance the beneficial effects of the ApoE2 allele, such as identifying compounds or lifestyle modifications that can promote lipid metabolism and cardiovascular health. These interventions aim to leverage the protective effects associated with the ApoE2 allele to improve overall health outcomes.
Yes, lifestyle and environmental factors can influence the effects of the ApoE2 protein. For example, individuals carrying the ApoE2 allele may benefit from maintaining a healthy lifestyle, including regular exercise, a balanced diet, and avoiding smoking and excessive alcohol consumption. These factors can help promote lipid metabolism and cardiovascular health.
While research is ongoing, some evidence suggests that lifestyle modifications, including regular exercise and a healthy diet, may enhance the beneficial effects of the ApoE2 protein. These lifestyle modifications can help maintain optimal lipid metabolism and cardiovascular health, potentially further reducing the risk of cardiovascular diseases and Alzheimer's disease.
While the ApoE2 allele may have potential protective effects against Alzheimer's disease, it has also been associated with an increased risk of other health conditions, such as hyperlipoproteinemia type III (a lipid disorder) and an increased risk of certain cardiovascular diseases.
Health outcomes are influenced by a complex interplay of genetic and environmental factors. The effects of the ApoE2 allele can be modified by other genetic variations, such as polymorphisms in genes related to lipid metabolism or inflammation. Understanding the interactions between ApoE2 and other genetic factors is an active area of research to better comprehend the overall impact on health outcomes.
The ApoE2 protein has a higher affinity for binding to lipids and cholesterol compared to other ApoE variants. This enhanced binding capacity may lead to improved clearance of cholesterol and triglycerides from the bloodstream, thus potentially reducing the risk of developing cardiovascular diseases.
The ApoE2 protein differs from the other ApoE variants primarily in its amino acid sequence. It is characterized by cysteine at positions 112 and 158, whereas ApoE3 has cysteine at position 112 and arginine at position 158, and ApoE4 has arginine at both positions.
While the ApoE2 allele has been associated with a reduced risk of developing Alzheimer's disease, carrying the allele does not guarantee complete protection. Other genetic and environmental factors can still influence an individual's risk for the disease.
While the ApoE2 allele is generally considered beneficial, it is important to note that its effects can differ depending on individual genetic and environmental factors. In rare cases, the presence of the ApoE2 allele may be associated with a higher risk of certain conditions, such as hyperlipoproteinemia type III, which can lead to elevated cholesterol and triglyceride levels.
Individuals with the ApoE2 allele can manage their health by following a healthy lifestyle, including regular physical activity, a well-balanced diet, and avoiding smoking and excessive alcohol consumption. Regular check-ups with healthcare professionals are also important to monitor lipid levels, cardiovascular health, and other relevant markers. Genetic counseling may also be beneficial for individuals to understand their genetic risks and make informed decisions about their health.
Research suggests that the ApoE2 allele may have a protective effect on cognitive function and brain health. It is associated with a lower risk of developing Alzheimer's disease and may also play a role in enhancing neuronal repair and regeneration in the brain.
There are no specific medical recommendations exclusively for individuals with the ApoE2 allele, as its effects vary based on individual factors. However, individuals with the ApoE2 allele may benefit from regular health check-ups to monitor lipid levels, cardiovascular health, and other relevant markers. Any medical recommendations should be personalized based on an individual's overall health profile and consideration of other risk factors.
While the ApoE2 allele is primarily associated with a reduced risk of Alzheimer's disease, it may also have some protective effects against other conditions. Studies have suggested a potential lower risk of certain cardiovascular diseases, including stroke and atherosclerosis, in individuals with the ApoE2 allele.
Yes, there are ongoing research studies and clinical trials exploring the potential benefits and applications of the ApoE2 protein. These studies aim to further understand the mechanisms and effects of ApoE2 and explore its potential therapeutic uses in various health conditions, including Alzheimer's disease and cardiovascular diseases.
Yes, the presence of the ApoE2 allele has been associated with differences in drug metabolism and response. For example, individuals with the ApoE2 allele may have altered responses to medications used for cardiovascular conditions and lipid-lowering therapies. Healthcare professionals should consider an individual's ApoE genotype when prescribing certain drugs to ensure optimal treatment outcomes.
The ApoE2 allele is less common compared to the ApoE3 and ApoE4 alleles. It has been observed to occur at higher frequencies in certain populations, such as African Americans and Asians, compared to individuals of European descent.
Yes, genetic testing can be performed to determine an individual's ApoE genotype. This can be done through various commercial genetic testing services. It is important to consult with a healthcare professional or genetic counselor to interpret the results and understand their implications properly.
Customer Reviews (4)
Write a reviewWhether I need assistance in experimental design, troubleshooting, or data interpretation, they provide prompt and personalized support, ensuring that my research progresses smoothly and efficiently.
the manufacturer ensures a streamlined supply chain management system to meet my trial's requirements.
The manufacturer's commitment to customer support and collaboration greatly enhances the overall research experience.
They provide a wealth of technical information and extensive documentation about the ApoE2 protein, ensuring I have a comprehensive understanding of its characteristics, handling protocols, and storage requirements.
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