Recombinant Human APOL2 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | APOL2-2388H |
Product Overview : | APOL2 MS Standard C13 and N15-labeled recombinant protein (NP_663612) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 37.1 kDa |
AA Sequence : | MNPESSIFIEDYLKYFQDQVSRENL LQLLTDDEAWNGFVAAAELPRDEAD ELRKALNKLASHMVMKDKNRHDKDQ QHRQWFLKEFPRLKRELEDHIRKLR ALAEEVEQVHRGTTIANVVSNSVGT TSGILTLLGLGLAPFTEGISFVLLD TGMGLGAAAAVAGITCSVVELVNKL RARAQARNLDQSGTNVAKVMKEFVG GNTPNVLTLVDNWYQVTQGIGRNIR AIRRARANPQLGAYAPPPHVIGRIS AEGGEQVERVVEGPAQAMSRGTMIV GAATGGILLLLDVVSLAYESKHLLE GAKSESAEELKKRAQELEGKLNFLT KIHEMLQPGQDQTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | APOL2 apolipoprotein L2 [ Homo sapiens (human) ] |
Official Symbol : | APOL2 |
Synonyms : | APOL2; apolipoprotein L, 2; apolipoprotein L2; APOL II; apolipoprotein L II; apolipoprotein L-II; APOL3; APOL-II; |
Gene ID : | 23780 |
mRNA Refseq : | NM_145637 |
Protein Refseq : | NP_663612 |
MIM : | 607252 |
UniProt ID : | Q9BQE5 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionYes, APOL2 plays a role in innate immunity. It is part of the APOL family of proteins, which are known to exhibit antimicrobial activity. APOL2 has been shown to exhibit potent activity against Trypanosoma brucei, a protozoan parasite that causes sleeping sickness in humans. This antimicrobial activity suggests that APOL2 contributes to the defense against certain pathogens.
APOL2 has been shown to interact with several proteins and molecules, suggesting its involvement in various cellular processes. Some of the known interacting partners of APOL2 include RAB7A, cathepsin D, and HSP90. These interactions suggest a role for APOL2 in endocytic pathways, lysosomal function, and protein folding. However, the full extent of APOL2's binding partners and their functional significance is still being explored.
APOL2 is expressed in various tissues, but its expression levels can vary depending on the tissue type. Studies have shown that APOL2 is expressed at higher levels in the liver, kidney, and spleen compared to other tissues. It is also found in other organs such as the heart, lung, and brain, albeit at lower levels. The tissue-specific expression patterns of APOL2 suggest that it may have distinct functions in different organs.
APOL2 has been implicated in cancer progression through various mechanisms. It is known to promote apoptosis in certain cancer cells, thereby inhibiting tumor growth. However, some studies have also suggested that APOL2 may have oncogenic properties and contribute to cancer cell survival and invasion. The exact role of APOL2 in cancer progression is still unclear and may vary depending on the cancer type and context.
APOL2 has been shown to bind to cholesterol and lipid molecules, suggesting a potential role in lipid metabolism. It may participate in the transport and regulation of cholesterol levels within cells.
Yes, there are known genetic variations in the APOL2 gene. Some studies have identified single nucleotide polymorphisms (SNPs) within the APOL2 gene that may be associated with various diseases, including cancer and cardiovascular disorders. However, further research is needed to confirm these associations and understand the functional consequences of these genetic variations.
The regulatory mechanisms controlling APOL2 expression are not fully understood. However, studies have identified some factors that can modulate APOL2 expression. For example, the transcription factor FoxO1 has been shown to regulate APOL2 expression, and its activation can upregulate APOL2 levels. Additionally, APOL2 expression has been found to be regulated by pro-inflammatory cytokines, such as interferon gamma (IFN-γ). Further research is needed to uncover the full range of regulatory mechanisms controlling APOL2 expression.
Currently, genetic testing specifically for APOL2 variants is not commonly available for diagnostic purposes or clinical use. However, as research on APOL2 and its potential implications progresses, there may be a growing interest in genetic testing for APOL2 variants in the future. It is advisable to consult with a healthcare professional or genetic counselor for more information about genetic testing options for APOL2 or similar genes.
APOL2 is evolutionarily conserved, meaning it is present in other species besides humans. It has been identified in various mammalian species, including chimpanzees, mice, and rats. However, the exact functions and roles of APOL2 in these other species may differ from humans.
There is ongoing research on APOL2 to further investigate its functions and potential associations with diseases. Scientists are exploring its involvement in cancer progression, cellular processes related to autophagy and apoptosis, and its interactions with other proteins. Additional research is necessary to fully elucidate the role of APOL2 in human health and disease.
The involvement of APOL2 in various diseases and cellular processes opens up potential therapeutic avenues. For example, considering its antimicrobial activity, targeting APOL2 or developing APOL2-derived peptides could potentially be used to treat infections caused by Trypanosoma brucei or other pathogens. Additionally, as APOL2 has been implicated in cancer progression, further studies may explore the therapeutic potential of targeting APOL2 for cancer treatment. However, more research is needed to fully understand the mechanisms of action of APOL2 and its therapeutic potential.
Yes, several genetic variations and mutations have been identified in the APOL2 gene. These genetic variants can result in different isoforms or alter the normal functioning of the APOL2 protein. For example, a genetic variant known as rs10772124 has been associated with increased risk of chronic kidney disease. Other studies have identified mutations in the APOL2 gene that are associated with increased susceptibility to certain parasitic infections, such as Trypanosoma cruzi, which causes Chagas disease. Further research is needed to fully understand the impact of these genetic variations and mutations on APOL2 function and disease susceptibility.
APOL2 has shown potential as a diagnostic or prognostic marker for certain diseases. For example, elevated APOL2 expression has been associated with poor prognosis in certain types of cancer, such as lung and gastric cancer. Additionally, APOL2 levels have been found to be altered in various diseases, including cardiovascular disorders, kidney disease, and diabetes. However, more research is needed to establish the clinical utility of APOL2 as a marker for disease diagnosis and prognosis.
APOL2 has been suggested to modulate apoptosis and autophagy pathways. It has been shown to induce apoptosis in certain cancer cells and may play a role in regulating cellular survival and death. Additionally, APOL2 has been linked to autophagy-related processes, which involve the degradation and recycling of cellular components.
While APOL2 has been investigated in various diseases, its specific role remains unclear. Some studies have suggested a potential involvement of APOL2 in certain cancers, including breast and colorectal cancer. However, further research is needed to better understand the connection, and more studies are required to establish APOL2's role in diseases definitively.
Yes, there are known protein-protein interactions involving APOL2. For example, it has been shown to interact with the Bcl-2 family of proteins, which are involved in the regulation of apoptosis. Additionally, APOL2 may interact with various lipid-binding proteins and receptors. These interactions are important for understanding the functional mechanisms of APOL2 and its potential roles in cellular processes.
Due to its involvement in various cellular processes and potential links to diseases such as cancer, APOL2 may have therapeutic implications. Further research may uncover its role as a target for drug development or as a biomarker in disease diagnosis and prognosis. However, more studies are required to fully understand the therapeutic potential of APOL2 and its clinical applications.
Customer Reviews (4)
Write a reviewThe manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.
The manufacturer's team of experts possesses a deep understanding of the APOL2 protein and its associated protocols.
This high-quality APOL2 protein provides researchers with confidence in obtaining accurate and reliable data during their investigations
In conclusion, using APOL2 protein in trials offers distinct advantages for researchers studying cell cycle regulation.
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