Recombinant Human APOL3 protein, His-tagged
Cat.No. : | APOL3-3731H |
Product Overview : | Recombinant Human APOL3 protein(246-380 aa), fused to His tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole. |
Protein length : | 246-380 aa |
AA Sequence : | SSAEAEASRLTATSIDRLKVFKEVM RDITPNLLSLLNNYYEATQTIGSEI RAIRQARARARLPVTTWRISAGSGG QAERTIAGTTRAVSRGARILSATTS GIFLALDVVNLVYESKHLHEGAKSA SAEELRRQAQ |
Purity : | 90%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. |
Gene Name : | APOL3 apolipoprotein L, 3 [ Homo sapiens ] |
Official Symbol : | APOL3 |
Synonyms : | APOL3; apolipoprotein L, 3; apolipoprotein L3; APOLIII; CG12 1; CG12_1; apoL-III; apolipoprotein L-III; TNF-inducible protein CG12-1; CG121; |
Gene ID : | 80833 |
mRNA Refseq : | NM_145640 |
Protein Refseq : | NP_663615 |
MIM : | 607253 |
UniProt ID : | O95236 |
Products Types
◆ Recombinant Protein | ||
APOL3-366H | Recombinant Human APOL3 Protein, His (Fc)-Avi-tagged | +Inquiry |
APOL3-713H | Recombinant Human APOL3 protein, GST-tagged | +Inquiry |
APOL3-3576H | Recombinant Human APOL3, His-tagged | +Inquiry |
◆ Lysates | ||
APOL3-8776HCL | Recombinant Human APOL3 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (9)
Ask a questionThe regulatory mechanisms governing APOL3 expression are not well characterized. However, studies have shown that APOL3 expression can be influenced by genetic and environmental factors, hormonal factors, and inflammatory stimuli. Further investigations are required to elucidate the precise mechanisms involved in the regulation of APOL3 expression.
APOL3 is primarily expressed in the liver, which is a major site of lipid metabolism. However, it is also found in other tissues such as the intestines, kidney, and adipose tissue, albeit at lower levels.
The exact interacting partners of APOL3 are not extensively characterized. However, APOL3 is known to interact with other apolipoproteins, such as apolipoprotein A1 (APOA1), as part of the HDL complex. These interactions contribute to the role of APOL3 in lipid metabolism and transport.
Specific pathological conditions directly linked to APOL3 mutations have not been extensively reported. However, variations in the APOL3 gene have been associated with dyslipidemia, altered lipid profiles, and an increased risk of cardiovascular diseases, as mentioned earlier.
Yes, genetic variations have been identified in the APOL3 gene. These include single nucleotide polymorphisms (SNPs) that can lead to changes in the protein structure or function. Some of these SNPs have been associated with altered lipid levels and increased risk for cardiovascular diseases.
The therapeutic potential of targeting APOL3 is currently unclear. It may have implications for lipid disorders and cardiovascular diseases, but more research is needed to determine whether modulating APOL3 levels or function could be a viable therapeutic approach.
Yes, ongoing research aims to further unravel the functions and mechanisms of APOL3. Scientists are investigating its role in lipid metabolism, atherosclerosis development, and potential therapeutic targeting. Additionally, studies are being conducted to explore the broader physiological functions of APOL3 in various biological processes and disease contexts.
Previous research has suggested that genetic variations in the APOL3 gene may be associated with an increased risk of cardiovascular diseases, including atherosclerosis and coronary artery disease. However, further studies are needed to fully understand the exact role of APOL3 in these conditions.
While the primary function of APOL3 is related to lipid metabolism, recent studies have suggested its involvement in additional processes. For instance, APOL3 has been implicated in modulating immune responses and regulating the growth and differentiation of certain cell types, indicating potential roles beyond lipid metabolism.
Customer Reviews (4)
Write a reviewThey can offer insights into interpreting results and assist in identifying trends or patterns that may be relevant to the specific research question.
The manufacturer's technical support can also aid researchers in the data analysis phase.
They can provide valuable guidance in experimental design, optimization, and troubleshooting, helping researchers overcome challenges and maximize the efficiency of their trials.
the manufacturer's technical support is instrumental in assisting researchers throughout their trials.
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