Recombinant Human AQP4 protein, His-tagged
Cat.No. : | AQP4-9731H |
Product Overview : | Recombinant Human AQP4(253-323aa) fused with His tag at N-terminal was expressed in Yeast. |
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Description : | This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
Source : | Yeast |
Species : | Human |
Tag : | His |
Molecular Mass : | 23.98kD |
Protein length : | 253-323aa |
AA Sequence : | CPDVEFKRRFKEAFSKAAQQTKGSY MEVEDNRSQVETDDLILKPGVVHVI DVDRGEEKKGKDQSGEVLSSV |
Storage : | If store at 2-8 centigrade, no more than 1 month; If store at -80 centigrade, no more than 12 month. Avoid multiple freeze-thaw cycles. |
Gene Name : | AQP4 aquaporin 4 [ Homo sapiens ] |
Official Symbol : | AQP4 |
Synonyms : | AQP4; aquaporin 4; aquaporin-4; MIWC; WCH4; aquaporin type4; mercurial-insensitive water channel; HMIWC2; MGC22454; |
Gene ID : | 361 |
mRNA Refseq : | NM_001650 |
Protein Refseq : | NP_001641 |
MIM : | 600308 |
UniProt ID : | P55087 |
Chromosome Location : | 18q11.2-q12.1 |
Pathway : | Aquaporin-mediated transport, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Passive Transport by Aquaporins, organism-specific biosystem; Regulation of Water Balance by Renal Aquaporins, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem; Vasopressin-regulated water reabsorption, organism-specific biosystem; |
Function : | transporter activity; water channel activity; water transmembrane transporter activity; |
Products Types
◆ Recombinant Protein | ||
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AQP4-1131H | Recombinant Human AQP4 Protein, His-SUMO-tagged | +Inquiry |
AQP4-203R | Recombinant Rhesus Macaque AQP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
AQP4-2226M | Recombinant Mouse AQP4 Protein (253-323 aa), His-tagged | +Inquiry |
Aqp4-2602R | Recombinant Rat Aqp4 protein, His & GST-tagged | +Inquiry |
◆ Lysates | ||
AQP4-32HCL | Recombinant Human AQP4 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionCurrently, there are no FDA-approved drugs that specifically target AQP4. However, several compounds have been investigated for their potential to modulate AQP4 function. For example, small molecule inhibitors or activators of AQP4 have been studied in preclinical models of brain edema and neurological disorders.
Currently, there are no FDA-approved drugs that specifically target AQP4. However, several compounds have been investigated for their potential to modulate AQP4 function. For example, small molecule inhibitors or activators of AQP4 have been studied in preclinical models of brain edema and neurological disorders.
Yes, the presence of autoantibodies against AQP4 can be used as a diagnostic marker for NMOSD. Detection of these antibodies in the serum or cerebrospinal fluid is a key component of the diagnostic criteria for NMOSD.
Yes, the presence of autoantibodies against AQP4 can be used as a diagnostic marker for NMOSD. Detection of these antibodies in the serum or cerebrospinal fluid is a key component of the diagnostic criteria for NMOSD.
In NMOSD, autoantibodies against AQP4 are believed to contribute to the pathogenesis of the disease. These autoantibodies bind to AQP4 in the central nervous system, causing complement-dependent inflammation and destruction of astrocytes. This leads to demyelination, neuronal damage, and clinical symptoms.
In NMOSD, autoantibodies against AQP4 are believed to contribute to the pathogenesis of the disease. These autoantibodies bind to AQP4 in the central nervous system, causing complement-dependent inflammation and destruction of astrocytes. This leads to demyelination, neuronal damage, and clinical symptoms.
AQP4 is found in the astrocytes surrounding blood vessels in the retina. It helps in the reabsorption of excess water from the retina, contributing to the maintenance of clear vision and the prevention of edema in the eye.
Yes, AQP4 is expressed in other organs as well. It is found in the kidneys, lungs, gastrointestinal tract, salivary glands, and other tissues where water transport is essential for their proper functioning.
Currently, there is no cure for NMOSD, but treatments aim to manage symptoms and prevent relapses. These may include immunosuppressive drugs, plasma exchange, and other supportive therapies.
AQP4 has been suggested as a potential therapeutic target for certain conditions. Strategies aimed at modulating AQP4 expression or function could have therapeutic implications in controlling brain water homeostasis, reducing edema, or managing diseases associated with AQP4 dysfunction. However, further research is needed to develop safe and effective therapies.
AQP4 has been suggested as a potential therapeutic target for certain conditions. Strategies aimed at modulating AQP4 expression or function could have therapeutic implications in controlling brain water homeostasis, reducing edema, or managing diseases associated with AQP4 dysfunction. However, further research is needed to develop safe and effective therapies.
Yes, genetic variations and mutations in the AQP4 gene have been identified. These variations can impact AQP4 function or expression and may contribute to the susceptibility or severity of certain neurological disorders such as NMOSD.
Yes, genetic variations and mutations in the AQP4 gene have been identified. These variations can impact AQP4 function or expression and may contribute to the susceptibility or severity of certain neurological disorders such as NMOSD.
Dysfunction or dysregulation of AQP4 can lead to brain edema, which is the accumulation of excess fluid in the brain tissue. Reduced AQP4 expression or altered localization may interfere with the clearance of water from brain cells, resulting in swelling and increased intracranial pressure.
AQP4 dysfunction or dysregulation has been implicated in various diseases and conditions, including brain edema, hydrocephalus, epilepsy, multiple sclerosis, and certain types of cancer. Research is ongoing to better understand the role of AQP4 in these conditions and explore potential therapeutic interventions.
AQP4 dysfunction or dysregulation has been implicated in various diseases and conditions, including brain edema, hydrocephalus, epilepsy, multiple sclerosis, and certain types of cancer. Research is ongoing to better understand the role of AQP4 in these conditions and explore potential therapeutic interventions.
Currently, there are clinical trials investigating the use of AQP4-targeted therapies for NMOSD. These trials are evaluating the efficacy and safety of drugs that aim to modulate AQP4 function or reduce the autoimmune response against AQP4.
Currently, there are clinical trials investigating the use of AQP4-targeted therapies for NMOSD. These trials are evaluating the efficacy and safety of drugs that aim to modulate AQP4 function or reduce the autoimmune response against AQP4.
Yes, AQP4 dysfunction has been strongly linked to neuromyelitis optica spectrum disorder (NMOSD), an autoimmune disease that primarily affects the optic nerves and spinal cord. Autoantibodies target AQP4, leading to inflammation and damage in these areas.
While its primary role is water transportation, studies suggest that AQP4 may play additional roles in cellular processes such as cell migration, neuroinflammation, and neuroprotection. However, further research is needed to fully understand these functions.
Customer Reviews (8)
Write a reviewIn addition to these experimental benefits, the manufacturer of Aqp4 protein plays a vital role in supporting researchers.
Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.
the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.
Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.
This partnership enhances research productivity while ensuring accurate and meaningful outcomes.
Aqp4 protein demonstrates exceptional stability and consistency, ensuring reliable and reproducible results throughout the duration of the trial.
Aqp4 protein exhibits high bioactivity, enabling efficient and effective interactions with its molecular targets.
The manufacturer's commitment to customer satisfaction extends beyond providing the protein itself.
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