Recombinant Human ARAP3 Protein, MYC/DDK-tagged
Cat.No. : | ARAP3-2584H |
Product Overview : | Recombinant Human ARAP3 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 169.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Homo sapiens ] |
Official Symbol : | ARAP3 |
Synonyms : | CENTD3; DRAG1 |
Gene ID : | 64411 |
mRNA Refseq : | NM_022481 |
Protein Refseq : | NP_071926 |
MIM : | 606647 |
UniProt ID : | Q8WWN8 |
Products Types
◆ Recombinant Protein | ||
Arap3-317M | Recombinant Mouse Arap3 Protein, MYC/DDK-tagged | +Inquiry |
ARAP3-9792H | Recombinant Human ARAP3, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (12)
Ask a questionARAP3 interacts with various proteins to perform its functions. Some of the known protein interactors of ARAP3 include Rho GTPases (such as RhoA, Rac1, and Cdc42), phosphoinositides (such as phosphatidylinositol 3,4,5-trisphosphate or PIP3), Src family kinases, protein kinases (such as protein kinase D or PKD), and scaffolding proteins (such as Eps8 and IRSp53). These interactions play a crucial role in ARAP3-mediated signaling and cellular processes.
ARAP3 has been associated with several diseases and conditions. Mutations or dysregulation of ARAP3 have been implicated in neurological disorders like autism spectrum disorders and intellectual disabilities. Additionally, ARAP3 has been implicated in cancer progression and metastasis. Further research is needed to fully understand the extent of ARAP3 involvement in various diseases and explore its potential as a therapeutic target.
Yes, ARAP3 has been found to play a role in immune responses. It can impact various immune cell functions, including T cell activation and migration, B cell signaling, and neutrophil recruitment. ARAP3 regulates specific signaling pathways and cytoskeletal rearrangements that are essential for immune cell activation and mobilization in response to immune challenges.
ARAP3 holds potential as a therapeutic target, particularly in diseases where its dysregulation contributes to pathological processes. Developing molecules that can modulate ARAP3 activity or disrupt its interactions with specific protein partners could provide avenues for therapeutic interventions. However, more research is necessary to explore the efficacy and safety of such interventions.
ARAP3 is evolutionarily conserved across various species, indicating its importance in cellular processes. Homologs of ARAP3 can be found in both vertebrates and invertebrates, suggesting a fundamental role in cellular function. However, there might be species-specific differences in the regulation or interaction partners of ARAP3.
Yes, ARAP3 has been implicated in neuronal development and function. It has been shown to regulate dendritic spine morphogenesis, synaptic plasticity, and neuronal migration. Defects in ARAP3 function may contribute to neurological disorders, such as autism spectrum disorders and intellectual disabilities.
Currently, I do not have specific information on ongoing studies or clinical trials focused on ARAP3. However, it is advisable to consult scientific databases, research publications, or clinical trial registries for the latest information on any ongoing investigations involving ARAP3.
Yes, ARAP3 interacts with several proteins to carry out its functions. For instance, it interacts with small GTPases, such as Arf and Rho, to control their activity and localize them to specific cellular compartments. ARAP3 also interacts with other signaling molecules and scaffolding proteins that mediate its effects on cellular processes.
Research suggests that dysregulation of ARAP3 expression or function may be involved in several diseases. For example, ARAP3 has been implicated in cancer progression and metastasis, as it promotes cell migration and invasion. Additionally, ARAP3 has been linked to cardiovascular diseases, such as atherosclerosis, as it influences endothelial cell migration and angiogenesis.
Yes, mutations in the ARAP3 gene have been identified in some individuals. These mutations can lead to alterations in the ARAP3 protein structure or function and may be associated with certain diseases or conditions. However, further research is needed to fully understand the implications of these mutations.
While specific inhibitors or activators of ARAP3 are currently limited, some molecules have been identified that can modulate ARAP3 activity indirectly. For example, various small molecules can inhibit ARAP3-mediated RhoA activation. Additionally, certain growth factors and signaling molecules can activate or regulate ARAP3 function. However, the development of specific targeted inhibitors or activators of ARAP3 is an area of ongoing research.
Yes, the expression of ARAP3 can be regulated by external cues or stimuli. For example, studies have shown that certain growth factors, hormones, or cellular stresses can influence ARAP3 expression levels in different cell types. The exact mechanisms underlying this regulation and its significance in various physiological or pathological contexts are areas of ongoing research.
Customer Reviews (8)
Write a reviewWith the manufacturer's excellent technical support and its wide range of applications, the ARAP3 protein has become an indispensable tool, aiding in my research endeavors and driving meaningful scientific discoveries.
the ARAP3 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.
The versatility of the ARAP3 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.
One notable advantage of using the ARAP3 protein is the outstanding technical support provided by its manufacturer.
Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.
Its seamless integration makes it possible to explore different research avenues, expanding the scope and impact of my investigations.
The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.
By using the ARAP3 protein in my experiments, I am confident in obtaining accurate and dependable data.
Ask a Question for All ARAP3 Products
Required fields are marked with *
My Review for All ARAP3 Products
Required fields are marked with *
Inquiry Basket