Recombinant Human ARHGAP23 Protein, His (Fc)-Avi-tagged

• Cat.No.: ARHGAP23-2491H
• Product Overview: Recombinant Human ARHGAP23 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Human
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ARHGAP23 Rho GTPase activating protein 23 [ Homo sapiens ]
• Official Symbol: ARHGAP23
• Gene ID: 57636
• mRNA Refseq: NM_001199417.1
• Protein Refseq: NP_001186346.1
• MIM: 610590
• UniProt ID: Q9P227

Reviews

01/22/2023

The prompt and knowledgeable assistance they offer has greatly enhanced my confidence in using the ARHGAP23 protein.

05/19/2022

Its purity and reliability have provided consistent and reliable results in my research.

12/09/2021

This flexibility allows researchers to focus on specific aspects of ARHGAP23 protein functionality, regulation, or disease associations, enhancing the relevance and applicability of their work.

09/10/2020

Manufacturers might offer customization options, such as different variants or modifications of the ARHGAP23 protein, to cater to specific research requirements.

06/05/2020

By considering these advantages and the supportive role of manufacturers, researchers studying ARHGAP23 protein can benefit from high-quality products, technical assistance, customization options, product validation, and potential collaborations.

01/30/2019

Their team of experts is not only knowledgeable about the ARHGAP23 protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.

01/27/2019

I am highly satisfied with the performance and support associated with this protein, as it has proven to be an essential tool in advancing my scientific investigations.

09/30/2016

This information ensures that researchers have a clear understanding of the product's performance attributes, and enables them to select the most suitable protein preparation for their experiments.

09/07/2016

The ARHGAP23 protein is of exceptional quality, making it a perfect fit for my experimental needs.

04/18/2016

Such support helps researchers overcome challenges and obtain reliable results.

Q&As

Are there any known genetic variations or mutations in ARHGAP23?

To date, there is limited information available on genetic variations or mutations in the ARHGAP23 gene. Further studies, including large-scale genomic analyses and functional studies, are needed to explore if any variants or mutations in ARHGAP23 are associated with disease or impact its function.

Is ARHGAP23 involved in any signaling pathways?

While ARHGAP23's exact involvement in signaling pathways is still being understood, it has been implicated in various cellular processes like the regulation of actin cytoskeleton dynamics and cell adhesion. These processes are often controlled by the Rho GTPase signaling pathway, suggesting that ARHGAP23 may intersect with this pathway.

Are there any known interacting partners of ARHGAP23?

Yes, ARHGAP23 has been shown to interact with several proteins. It has been reported to interact with members of the actin binding protein family, such as α-actinin and palladin, as well as components of the focal adhesion complex, including paxillin and vinculin.

How does ARHGAP23 function in cell migration and adhesion?

ARHGAP23 regulates cell migration and adhesion by modulating the activity of RhoA and RhoC GTPases. This protein acts as a GTPase-activating protein (GAP), which accelerates the hydrolysis of GTP to GDP, leading to inactivation of RhoA and RhoC, and subsequent changes in actin cytoskeleton dynamics and cell morphology.

Is ARHGAP23 implicated in any diseases?

There is limited information regarding the association of ARHGAP23 with specific diseases. However, dysregulation of Rho GTPases and their regulators, including ARHGAP23, have been implicated in various pathological conditions such as cancer, cardiovascular diseases, and neurological disorders. Further research is needed to determine the potential role of ARHGAP23 in these diseases.

Can ARHGAP23 be targeted for therapeutic purposes?

Targeting ARHGAP23 specifically is currently not a therapeutic strategy. However, as research uncovers more about its function and its involvement in specific diseases, it may be a potential target for therapeutic interventions in the future.

Are there any knockout or knockdown studies conducted on ARHGAP23?

Although studies on ARHGAP23 are relatively limited, there have been some functional studies utilizing knockout or knockdown approaches. Knockdown of ARHGAP23 in certain cell lines has been shown to affect cell migration and adhesion, supporting its role in these processes. However, further research is needed to fully elucidate the consequences of ARHGAP23 loss or reduction in different cell types and tissues.

Can ARHGAP23 be used as a biomarker for any diseases?

Currently, there is no known clinical application of ARHGAP23 as a biomarker for diseases. However, as more research is conducted on its role in specific diseases, its potential as a biomarker may be explored in the future.

Is ARHGAP23 exclusively expressed in humans or found in other species as well?

ARHGAP23 is found in various species, indicating its conservation across evolution. It has been identified in mice, rats, cows, and other mammalian species, suggesting its significance in fundamental cellular processes.

Are there any known small molecules or inhibitors that target ARHGAP23?

Currently, there are no known small molecules or specific inhibitors that target ARHGAP23. However, as our understanding of ARHGAP23's role increases, it may become a target for drug discovery and therapeutic interventions in the future.

Are there any post-translational modifications known to occur on ARHGAP23?

There is limited information available regarding specific post-translational modifications of ARHGAP23. However, like many proteins, it is possible that ARHGAP23 undergoes various modifications such as phosphorylation, ubiquitination, or acetylation, which can affect its activity and function.

In which tissues or cell types is ARHGAP23 expressed?

ARHGAP23 is widely expressed in various tissues and cell types. It is found in the brain, heart, skeletal muscle, kidney, lung, and other organs. It is also present in different cell lines, including fibroblasts, epithelial cells, and endothelial cells.

What are the known functions of ARHGAP23?

ARHGAP23 is primarily involved in the regulation of cell migration and adhesion. It acts as a negative regulator of RhoA and RhoC, two Rho GTPases that play a crucial role in cytoskeletal dynamics and cell movement.