Recombinant Human ARID3B, GST-tagged

• Cat.No.: ARID3B-9843H
• Product Overview: Recombinant Human ARID3B protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 208-562a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ARID3B AT rich interactive domain 3B (BRIGHT-like) [ Homo sapiens ]
• Official Symbol: ARID3B
• Synonyms: ARID3B; AT rich interactive domain 3B (BRIGHT-like); AT rich interactive domain 3B (BRIGHT like); AT-rich interactive domain-containing protein 3B; BDP; DRIL2; bright-like protein; bright and dead ringer protein; ARID domain-containing protein 3B; AT rich interactive domain 3B (BRIGHT- like)
• Gene ID: 10620
• mRNA Refseq: NM_006465
• Protein Refseq: NP_006456
• MIM: 612457
• UniProt ID: Q8IVW6
• Chromosome Location: 15q24
• Function: DNA binding

Reviews

01/11/2023

ARID3B protein exhibits high bioactivity, enabling efficient and effective interactions with its molecular targets.

12/12/2022

The ARID3B protein exhibits exceptional quality, making it an ideal choice to meet my experimental requirements.

12/17/2021

They offer comprehensive technical support, including responsive customer service, availability of product information, and timely delivery of the product.

08/25/2021

The manufacturer's responsive and knowledgeable support system promptly addresses any questions or concerns I may have, greatly streamlining my research process.

07/26/2020

the manufacturer's customer-centric approach highlights their focus on ensuring my satisfaction.

01/22/2020

The manufacturer's commitment to customer satisfaction extends beyond providing the protein itself.

11/04/2018

This commitment ensures that I have access to the most advanced and reliable protein available, enhancing the integrity and impact of my experiments.

04/22/2017

ARID3B protein demonstrates exceptional stability and consistency, ensuring reliable and reproducible results throughout the duration of the trial.

Q&As

Is ARID3B localized to specific cellular compartments?

ARID3B is primarily localized in the nucleus, consistent with its role as a transcription factor. It contains a nuclear localization signal (NLS) that facilitates its transport into the nucleus, where it can interact with DNA and other proteins to regulate gene expression.

Can ARID3B be a potential therapeutic target?

As our understanding of ARID3B's functions and involvement in diseases is still evolving, it is premature to determine its potential as a therapeutic target. However, future research may shed light on its relevance in diseases and whether it could be harnessed for therapeutic interventions.

Are there any known mutations or genetic variants associated with ARID3B?

There is limited information regarding mutations or genetic variants specifically linked to ARID3B. Genetic studies examining ARID3B in various diseases or disorders are still ongoing, and further research is required to determine if any specific mutations or genetic variations in ARID3B contribute to specific conditions.

Are there any known diseases or disorders associated with ARID3B mutations?

At present, there is limited information regarding diseases or disorders specifically linked to ARID3B mutations. However, dysregulation of ARID3B has been implicated in various types of cancer, including hepatocellular carcinoma and neuroblastoma. Further research is needed to understand the specific role of ARID3B mutations in these diseases and to determine if they are associated with other conditions.

Is ARID3B involved in embryonic development?

Yes, there is evidence suggesting that ARID3B plays a role in embryonic development. Studies in mice have shown that ARID3B is expressed in early embryonic stages and is involved in the regulation of cell growth and survival during development. However, the precise mechanisms and targets of ARID3B in embryogenesis are still not fully understood.

Is there any evidence of ARID3B involvement in neural development or function?

Yes, there is evidence suggesting that ARID3B plays a role in neural development and function. Studies have shown that ARID3B is highly expressed in the developing brain and is involved in neuronal differentiation and survival. It may also be involved in neural stem cell maintenance and gliogenesis, contributing to the formation and function of the nervous system.

Are there any known regulatory elements or transcription factors that control ARID3B expression?

The regulatory elements and transcription factors that control ARID3B expression are not well-characterized. However, some studies suggest that ARID3B expression can be regulated by signaling pathways such as Wnt and Notch, as well as through epigenetic modifications like DNA methylation and histone modifications. Further research is needed to fully elucidate the regulatory mechanisms governing ARID3B expression.

Does ARID3B have any known interaction partners?

ARID3B has been found to interact with various proteins involved in gene regulation and embryonic development. It has been reported to associate with transcription factors such as BRN2 and SOX2, as well as chromatin remodeling complexes like BAF and NuRD. These interactions suggest that ARID3B collaborates with other factors to regulate gene expression and cellular processes.

What are the current research directions for ARID3B?

Due to the limited knowledge about ARID3B, the current research focus is primarily directed towards understanding its molecular functions, interaction partners, and potential roles in development and disease. Researchers are exploring its involvement in gene regulation, embryonic development, and potentially identifying any links to specific diseases or disorders.

How is ARID3B different from ARID3A?

While ARID3A and ARID3B are related proteins, they have distinct functions and expression patterns. ARID3B is expressed in a more restricted manner compared to ARID3A, with higher levels observed in the brain and testis. Furthermore, ARID3B has been found to have a different DNA binding specificity compared to ARID3A.