Recombinant Human ARL11, His-tagged
Cat.No. : | ARL11-3557H |
Product Overview : | Recombinant human ARL11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (1-196aa). |
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Cat. No. : | ARL11-3557H |
Description : | ARL11(ADP-ribosylation factor-like protein 11), is a member of the ARF family of the Ras superfamily of small GTPases that are known to be involved in multiple regulatory pathways altered in human carcinogenesis. ARFs are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of choleratoxin. ARFs are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL11 is thought to function as a tumor suppressor that may play a role in the regulation of apoptosis. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 30% glycerol, 100mM NaCl, 1mM EDTA. |
Molecular Weight : | 23.6kDa (216aa), confirmed by MALDI-TOF |
Purity : | > 90% by SDS - PAGE |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS. |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | ARL11 ADP-ribosylation factor-like 11 [ Homo sapiens ] |
Official Symbol : | ARL11 |
Synonyms : | ARL11;ADP-ribosylation factor-like 11; ARLTS1; FLJ33930; MGC17429; ADP-ribosylation factor-like protein 11; OTTHUMP00000018420; ADP-ribosylation factor-like tumor suppressor protein 1 |
Gene ID : | 115761 |
mRNA Refseq : | NM_138450 |
Protein Refseq : | NP_612459 |
MIM : | 609351 |
UniProt ID : | Q969Q4 |
Chromosome Location : | 13q14.2 |
Function : | GTP binding; nucleotide binding; protein binding |
Products Types
◆ Recombinant Protein | ||
ARL11-433R | Recombinant Rat ARL11 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARL11-226R | Recombinant Rhesus Macaque ARL11 Protein, His (Fc)-Avi-tagged | +Inquiry |
Arl11-1702M | Recombinant Mouse Arl11 Protein, Myc/DDK-tagged | +Inquiry |
ARL11-716M | Recombinant Mouse ARL11 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARL11-1922M | Recombinant Mouse ARL11 Protein | +Inquiry |
◆ Lysates | ||
ARL11-8722HCL | Recombinant Human ARL11 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionLimited information is available regarding post-translational modifications (PTMs) of Arl11. However, like other GTPases, Arl11 may undergo PTMs such as phosphorylation, acetylation, or lipidation. These modifications can potentially regulate its activity, localization, and binding partners.
Arl11 is evolutionarily conserved among various species, including mammals, birds, reptiles, and amphibians. Its conservation suggests a functional importance, although the extent of its conservation and specific roles may differ across different organisms.
Limited studies have been conducted on the expression pattern of Arl11. However, available data suggests that Arl11 is expressed in various tissues and cells, although the specific levels and localization may vary.
Currently, there is limited information available regarding the involvement of Arl11 in cancer. However, recent studies have suggested potential associations between altered expression of Arl11 and certain types of cancer, indicating a possible role in tumor biology. Further investigations are needed to determine its precise contribution to cancer development and progression.
To date, there are no known animal models specifically targeting Arl11. Developing animal models, such as knockout or transgenic mice, could provide valuable insights into the physiological functions of Arl11 and its potential implications in human health and disease.
As of now, there are no known drugs or specific inhibitors developed to directly target Arl11. The lack of comprehensive studies on Arl11's involvement in diseases has limited the development of therapeutic interventions. Identification of small molecule modulators or inhibitors may require further research.
The binding partners or interactors of Arl11 have not been extensively characterized. Further research is needed to identify potential protein partners that interact with Arl11 and determine their functional significance.
While vesicle trafficking is the most commonly suggested function of Arl11, its role in other cellular processes cannot be ruled out. Further research may uncover additional functions and pathways influenced by Arl11, contributing to a comprehensive understanding of its biological roles.
Customer Reviews (8)
Write a reviewBy incorporating Arl11 protein into electron microscopy studies, researchers have gained valuable insights into protein interactions and conformational changes, contributing to a deeper understanding of complex cellular processes.
Their extensive technical expertise and assistance are invaluable in overcoming any challenges that may arise during the experimental process.
Its stability and well-defined structure make it an excellent candidate for visualizing and studying the three-dimensional arrangement of proteins at a high resolution.
Its reliability in ELISA makes it a trusted tool for quantitative and qualitative protein analysis.
the manufacturer's commitment to customer satisfaction extends beyond technical support. They offer a comprehensive range of related products and resources to aid researchers in their trials.
Ankar protein has been successfully utilized in protein electron microscopy structure analysis.
From troubleshooting to optimizing experimental protocols, the manufacturer provides diligent support to ensure the success of the trial.
This property is particularly beneficial for long-term trials or experiments with extended durations, ensuring consistent performance throughout the entire study period.
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