Recombinant Human ARL13B 293 Cell Lysate
Cat.No. : | ARL13B-8720HCL |
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Description : | Antigen standard for ADP-ribosylation factor-like 13B (ARL13B), transcript variant 2 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Gene Name : | ARL13B ADP-ribosylation factor-like 13B [ Homo sapiens ] |
Official Symbol : | ARL13B |
Synonyms : | ARL13B; ADP-ribosylation factor-like 13B; ADP ribosylation factor like 2 like 1 , ARL2L1; ADP-ribosylation factor-like protein 13B; DKFZp761H079; JBTS8; ARL2-like protein 1; ADP-ribosylation factor-like 2-like 1; ARL2L1; MGC120611; MGC120612; DKFZp686E2075; DKFZp686L2472; DKFZp686M2074; |
Gene ID : | 200894 |
mRNA Refseq : | NM_144996 |
Protein Refseq : | NP_659433 |
MIM : | 608922 |
UniProt ID : | Q3SXY8 |
Chromosome Location : | 3q11 |
Function : | GTP binding; nucleotide binding; |
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◆ Lysates | ||
ARL13B-8721HCL | Recombinant Human ARL13B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionYes, researchers have developed animal models, such as mice and zebrafish, with specific ARL13B gene mutations. These models help in studying the consequences of ARL13B dysfunction and its role in cilia-related diseases, providing valuable insights into the biology of ciliopathies.
Yes, ARL13B can interact with various proteins involved in ciliary pathways. It interacts with other ciliary proteins, such as intraflagellar transport (IFT) proteins and BBSome components, to regulate protein trafficking and signaling within cilia.
While ARL13B primarily functions within cilia, studies suggest that it may have additional roles outside of cilia. It has been shown to interact with components of the Golgi apparatus, suggesting potential involvement in intracellular vesicle trafficking and Golgi organization.
Currently, there are no specific pharmacological agents targeting ARL13B. However, research is being conducted on compounds that modulate ciliary function and may indirectly affect ARL13B activity. These compounds hold potential for future therapeutic interventions for ciliopathy-related disorders.
ARL13B has been suggested as a potential biomarker for ciliopathies. Its altered expression or cellular localization in patient samples may serve as indicators of ciliary dysfunction and contribute to the diagnosis and study of these disorders.
Yes, mutations in the ARL13B gene can be inherited in an autosomal recessive manner. This means that both parents must be carriers of a mutated ARL13B allele to pass on the disorder to their offspring.
Yes, research on ARL13B is actively ongoing. Scientists continue to investigate its precise mechanisms of action, its interactions with other proteins, and its role in ciliopathy-related disorders. This research aims to improve our understanding of ciliogenesis and develop potential therapeutic strategies for ciliopathy treatment.
ARL13B is conserved across various species, indicating its importance in ciliary biology. Homologs of ARL13B can be found in organisms ranging from worms to humans, suggesting its fundamental role in ciliogenesis and cilia-related processes.
Targeting ARL13B directly for therapeutic purposes is challenging due to its essential role in ciliogenesis. However, research efforts are focused on finding ways to modulate downstream targets or pathways regulated by ARL13B to restore ciliary function and ameliorate ciliopathy-related symptoms.
Yes, mutations in the ARL13B gene have been linked to a range of ciliopathies, including Joubert syndrome, oral-facial-digital syndrome type VI (OFDVI), and Bardet-Biedl syndrome (BBS). These disorders are characterized by various clinical features, including neurological and cognitive impairments, kidney dysfunction, and skeletal abnormalities.
ARL13B is involved in regulating ciliary signaling pathways, such as Hedgehog signaling. It helps to localize and control the trafficking of key components involved in these pathways, ensuring the proper activation and transmission of signals within the primary cilium.
ARL13B plays a crucial role in the assembly and maintenance of cilia by controlling the trafficking of key components required for cilia formation. It helps in the targeting and delivery of proteins to the ciliary membrane, ensuring the proper assembly and function of this organelle.
Currently, there are no clinical trials specifically targeting ARL13B. However, clinical trials are being conducted for various ciliopathy disorders, including those associated with ARL13B mutations. These trials explore potential treatments and interventions to manage the symptoms and complications of ciliopathies.
Yes, ARL13B is essential for proper embryonic development. Mutations in the ARL13B gene can cause a variety of ciliopathies, affecting multiple organ systems and leading to developmental abnormalities.
Customer Reviews (10)
Write a reviewmanufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.
Collaborating with the manufacturer opens up possibilities for potential collaboration and exchange of information with a wider scientific community, allowing researchers to stay at the forefront of advancements in their respective fields.
The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.
the manufacturer of ARL13B protein provides excellent technical support, ensuring prompt assistance and guidance.
This includes complementary reagents, protocols, and access to an extensive knowledge base, all aimed at streamlining the trial process and maximizing the chances of achieving meaningful results.
Its unique properties and functions make it an essential component in investigating various biological processes and molecular mechanisms.
Their expertise and commitment to customer satisfaction make them a trusted partner in achieving research goals.
Their knowledgeable team is readily available to address any questions or concerns, guaranteeing a smooth experimental process.
the manufacturer of ARL13B protein provides excellent technical support, ensuring prompt assistance and guidance.
the ARL13B protein offers numerous advantages for researchers conducting trials due to its high quality and stability.
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