Recombinant Human ARL4A protein, His-tagged

• Cat.No.: ARL4A-2550H
• Product Overview: Recombinant Human ARL4A protein(P40617)(2-200aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 26.5 kDa
• Protein length: 2-200aa
• AA Sequence: GNGLSDQTSILSNLPSFQSFHIVIL GLDCAGKTTVLYRLQFNEFVNTVPT KGFNTEKIKVTLGNSKTVTFHFWDV GGQEKLRPLWKSYTRCTDGIVFVVD SVDVERMEEAKTELHKITRISENQG VPVLIVANKQDLRNSLSLSEIEKLL AMGELSSSTPWHLQPTCAIIGDGLK EGLEKLHDMIIKRRKMLRQQKKKR
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: ARL4A ADP-ribosylation factor-like 4A [ Homo sapiens ]
• Official Symbol: ARL4A
• Synonyms: ARL4A; ADP-ribosylation factor-like 4A; ADP ribosylation factor like 4 , ARL4; ADP-ribosylation factor-like protein 4A; ADP-ribosylation factor-like 4; ARL4
• Gene ID: 10124
• mRNA Refseq: NM_001037164
• Protein Refseq: NP_001032241
• MIM: 604786
• UniProt ID: P40617

Reviews

11/13/2022

The versatility of the ARL4A protein makes it a valuable asset in my research.

11/05/2022

The ARL4A protein is renowned for its exceptional quality, making it a perfect match for my experimental requirements.

03/25/2019

the ARL4A protein exhibits superior performance across a range of experimental applications.

09/30/2018

In addition to its high-quality attributes, the manufacturer of the ARL4A protein offers exemplary technical support.

06/14/2017

Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.

06/10/2017

Whether I am studying protein interactions, cellular localization, or signaling pathways, the ARL4A protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.

01/26/2016

Its versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.

01/16/2016

Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.

Q&As

Are there any known disease associations or mutations in the ARL4A gene?

Mutations in the ARL4A gene have not been extensively studied. However, some studies have suggested its potential involvement in cancer progression and metastasis. Further research is required to fully understand any disease associations or potential therapeutic implications.

Can dysregulation of ARL4A expression lead to any cellular defects?

Dysregulation of ARL4A expression has been implicated in various pathological conditions. Alterations in its expression levels or activity may contribute to abnormalities in vesicular trafficking, cytoskeletal organization, and overall cellular homeostasis.

Does ARL4A interact with other proteins?

Yes, ARL4A interacts with several proteins to regulate various cellular processes. It can interact with GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs), and effector proteins involved in vesicle trafficking and cytoskeletal dynamics.

Is ARL4A involved in any signaling pathways?

ARL4A itself is not considered a signaling molecule in canonical signaling pathways. However, it may modulate the activity of certain signaling molecules by regulating their intracellular transport or localization.

In which tissues or cell types is ARL4A expressed?

ARL4A is generally expressed in a wide range of tissues and cell types, indicating its ubiquitous nature. Its expression may vary in different tissues and developmental stages.

Can the ARL4A protein be targeted for therapeutic purposes?

The therapeutic potential of targeting ARL4A is currently being explored. Its involvement in cellular processes and potential role in diseases make it a potential therapeutic target. However, further research is needed to fully understand its mechanisms and implications for targeted therapeutics.