Recombinant Human ARMC4 protein, GST-tagged

• Cat.No.: ARMC4-828H
• Product Overview: Human ARMC4 partial ORF ( NP_060546, 945 a.a. - 1044 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 36.74 kDa
• AA Sequence: AISRCCMWGRNRVAFGEHKAVAPLV RYLKSNDTNVHRATAQALYQLSEDA DNCITMHENGAVKLLLDMVGSPDQD LQEAAAGCISNIRRLALATEKARYT
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ARMC4 armadillo repeat containing 4 [ Homo sapiens ]
• Official Symbol: ARMC4
• Synonyms: ARMC4; armadillo repeat containing 4; armadillo repeat-containing protein 4; DKFZP434P1735; FLJ10376; FLJ10817; FLJ32798; RP11-691I13.1; DKFZp434P1735
• Gene ID: 55130
• mRNA Refseq: NM_018076
• Protein Refseq: NP_060546
• UniProt ID: Q5T2S8

Reviews

01/06/2021

This ensures the consistency and reproducibility of experimental results, promoting confidence in the obtained data.

08/11/2020

This commitment to staying at the forefront of research translates directly to the quality and performance of the ARMC4 protein in my trials.

07/25/2019

the ARMC4 Protein's applicability in protein electron microscopy structure analysis is remarkable.

04/05/2019

As a researcher, utilizing ARMC4 protein in trials offers numerous advantages that contribute to the successful completion of experiments and the acquisition of valuable data.

11/11/2017

They monitor the latest advancements in the field and incorporate new findings into the production and characterization of the protein.

11/09/2017

ARMC4, a calcium-dependent phospholipid-binding protein, plays a crucial role in various cellular processes, making it a valuable tool for investigation.

Q&As

Does ARMC4 protein play a role in cell migration or adhesion?

The involvement of ARMC4 protein in cell migration and adhesion processes is not well-established. However, it may interact with proteins involved in cytoskeletal dynamics, suggesting possible roles in these cellular processes.

Is the expression of ARMC4 protein regulated during different developmental stages?

The expression of ARMC4 protein may vary during different developmental stages and in specific tissues, suggesting potential roles in development. However, more comprehensive studies are needed to fully understand its regulatory pattern.

Are there any known post-translational modifications of ARMC4 protein?

Currently, there is limited information regarding post-translational modifications of ARMC4 protein. Future research is needed to explore potential modifications and their functional implications.

Is ARMC4 protein conserved across different species?

Yes, ARMC4 protein is evolutionarily conserved across different species, suggesting its importance and potentially conserved function.

Are there any diseases associated with mutations in ARMC4 protein?

Yes, studies have linked ARMC4 genetic variations to a higher risk of neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability (ID). However, more research is necessary to establish a direct causal relationship.

Are there any known interacting partners of ARMC4 protein?

The specific interacting partners of ARMC4 protein have not been extensively characterized. Further research is needed to uncover its potential binding partners and regulatory interactions.

Can ARMC4 protein be targeted therapeutically?

As our understanding of ARMC4 protein's function is still evolving, no specific therapeutic targeting strategies have been developed so far. Further research is required to elucidate its precise roles and therapeutic potential.