Recombinant Human ARMS2, His-tagged

• Cat.No.: ARMS2-3237H
• Product Overview: Age-related maculopathy susceptibility protein 2 (ARMS2)

Specification

• Description: This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration.
• Source: E. Coli or Yeast
• Species: Human
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 107
• Purity: >90%
• Notes: Small volumes of ARMS2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: ARMS2 age-related maculopathy susceptibility 2 [ Homo sapiens ]
• Official Symbol: ARMS2
• Synonyms: ARMS2; age-related maculopathy susceptibility 2; age-related maculopathy susceptibility protein 2; LOC387715; ARMD8
• Gene ID: 387715
• mRNA Refseq: NM_001099667
• Protein Refseq: NP_001093137
• MIM: 611313
• UniProt ID: P0C7Q2
• Chromosome Location: 10q26.13

Reviews

06/26/2022

Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

03/24/2022

The ARMS2 protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.

08/19/2020

the ARMS2 protein has proven to be invaluable in protein electron microscopy structure analysis.

05/29/2019

This information is crucial for researchers in understanding the protein's behavior and interaction within their specific experimental context.

03/26/2017

ARMS2 is known for its high purity and quality, ensuring accurate and reproducible results.

02/21/2016

The manufacturer offers exceptional technical assistance, guiding researchers through various stages of their experiments.

Q&As

Is there any evidence suggesting a role for the ARMS2 protein in other biological processes?

While the primary association of the ARMS2 protein is with AMD, some studies have suggested its involvement in other cellular processes such as apoptosis, cell proliferation, and lipid metabolism. However, further research is needed to fully understand these potential roles.

Are there any known interactions between the ARMS2 protein and other molecules?

Yes, the ARMS2 protein has been found to interact with other proteins and cellular components within the mitochondria, including members of the mitochondrial processing peptidase (MPP) complex.

Are there any animal models used to study the ARMS2 protein and its implications?

Yes, researchers have developed various animal models, such as mice and zebrafish, to study the function of the ARMS2 protein and its role in age-related macular degeneration (AMD). These models allow for the investigation of ARMS2 gene mutations and their effects on retinal structure and function.

Is there a link between ARMS2 protein and other systemic diseases?

Currently, there is no well-established link between the ARMS2 protein and systemic diseases. However, studies have suggested potential associations between ARMS2 gene variants and conditions like cardiovascular diseases and Alzheimer's disease. More research is needed to ascertain these connections and understand the underlying mechanisms.

Can lifestyle factors or environmental factors influence the expression or function of the ARMS2 protein?

While genetics play a significant role in AMD development, environmental factors such as smoking and diet may influence the expression or function of the ARMS2 protein. However, the exact relationship between these factors and the ARMS2 protein is still being investigated.

Are there any known drugs or therapies that target the ARMS2 protein?

Currently, there are no specific drugs or therapies that directly target the ARMS2 protein. Treatment for AMD primarily focuses on managing the symptoms and preventing disease progression, such as through anti-angiogenic drugs or laser therapy.

Can mutations in the ARMS2 gene lead to other eye diseases or conditions?

Mutations in the ARMS2 gene have primarily been associated with age-related macular degeneration (AMD). However, there is limited evidence suggesting a possible association between ARMS2 gene mutations and other eye conditions, such as polypoidal choroidal vasculopathy and pachychoroid neovasculopathy. Further research is necessary to establish these associations.

Are there any known drugs or interventions that can specifically target the ARMS2 protein?

Currently, there are no drugs or interventions specifically targeting the ARMS2 protein. Most therapeutic approaches for AMD focus on mitigating its downstream effects, such as anti-vascular endothelial growth factor (VEGF) therapies. Research is ongoing to identify potential ARMS2-targeted treatments or interventions.

Can changes in ARMS2 protein expression levels be detected and monitored over time?

Changes in ARMS2 protein expression levels can be monitored through various laboratory techniques, such as Western blotting and immunohistochemistry. These methods allow for the detection and quantification of ARMS2 protein levels in biological samples, such as retinal tissues or cells, providing insights into its expression changes over time.

Are there any known interactions between the ARMS2 protein and other proteins or molecules?

The exact protein-protein interactions of the ARMS2 protein are not well-characterized. However, studies have suggested potential interactions with proteins involved in mitochondrial function, oxidative stress, and inflammation. Further research is needed to fully elucidate the protein interactions and molecular pathways involving ARMS2.

Is the ARMS2 protein associated with any diseases?

Yes, genetic variations in the ARMS2 gene have been strongly linked to the development of age-related macular degeneration (AMD), a leading cause of vision loss in older adults.

Can ARMS2 gene variants be used as genetic markers for AMD risk assessment?

Certain genetic variations in the ARMS2 gene, such as the rs10490924 and rs11200638 single nucleotide polymorphisms (SNPs), have been identified as significant risk factors for AMD. However, their predictive value in individual risk assessment is limited due to the complex interactions between genetic and environmental factors in AMD development. Genetic testing for ARMS2 variants may provide some insights into an individual's susceptibility to AMD, but it is not currently considered a definitive diagnostic tool.

Is the ARMS2 protein found in tissues other than the retina?

While the ARMS2 protein is primarily associated with the retina and age-related macular degeneration, it has been found in low levels in other tissues, including the brain, heart, liver, and kidney. However, its function in these tissues is not well understood.

Are there any ongoing research efforts to investigate the ARMS2 protein and AMD?

Yes, researchers continue to study the role of the ARMS2 protein in AMD, aiming to uncover its exact function, mechanisms of action, and potential therapeutic targets. This research can potentially lead to the development of novel treatments for AMD.

Can the ARMS2 protein be used as a biomarker for AMD?

Genetic variations in the ARMS2 gene can serve as biomarkers for increased susceptibility to AMD. Testing for these variations can help identify individuals who may have a higher risk of developing the disease.

How does the ARMS2 protein contribute to age-related macular degeneration?

The precise mechanisms by which the ARMS2 protein contributes to AMD are not yet fully understood. However, it is believed that genetic variations in the ARMS2 gene may lead to dysfunctional ARMS2 protein or altered expression levels, resulting in increased susceptibility to oxidative stress and inflammation in the retina, ultimately leading to AMD.