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Recombinant Human ARNT protein, GST-tagged

Cat.No.: ARNT-288H
Product Overview: Recombinant Human ARNT fused with GST tag at N-terminal was expressed in Insect cells.
Description: The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), alternatively named Hypoxia-inducible factor (HIF)-1β, is part of the Hypoxia-inducible factor (HIF) pathway which mediates cellular adaptations to hypoxia and promotes tumour progression. Unlike HIF-1α that is regulated in an oxygen-dependent manner, HIF-1β is constitutively expressed. It has been shown that some tumour cells are capable to elevate HIF-1β in response to hypoxia to for a clonal advantage. HIF-1β binds HIF-1α, and forms the transcriptional active HIF-1 complex in the nucleus.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: 120 kDa
Purity: > 70%
Applications: Western Blot
Stability: 1 year at -70 centigrade from the date of shipment.
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens ]
Official Symbol: ARNT
Synonyms: ARNT; aryl hydrocarbon receptor nuclear translocator; bHLHe2; HIF 1beta; dioxin receptor, nuclear translocator; class E basic helix-loop-helix protein 2; hypoxia-inducible factor 1, beta subunit; HIF1B; TANGO; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta;
Gene ID: 405
mRNA Refseq: NM_001668
Protein Refseq: NP_001659
MIM: 126110
UniProt ID: P27540
Chromosome Location: 1q21
Pathway: Angiogenesis, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Pathways in cancer, organism-specific biosystem; Renal cell carcinoma, organism-specific biosystem;
Function: aryl hydrocarbon receptor activity; aryl hydrocarbon receptor binding; protein binding; protein heterodimerization activity; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; contributes_to sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription coactivator activity; transcription factor binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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