Recombinant Human ARPC5L protein, GST-tagged

• Cat.No.: ARPC5L-850H
• Product Overview: Human ARPC5L full-length ORF ( NP_112240.1, 1 a.a. - 153 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: ARPC5L (Actin Related Protein 2/3 Complex Subunit 5 Like) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling and Salmonella infection (KEGG). GO annotations related to this gene include actin binding. An important paralog of this gene is ARPC5.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 43.3 kDa
• AA Sequence: MARNTLSSRFRRVDIDEFDENKFVD EQEEAAAAAAEPGPDPSEVDGLLRQ GDMLRAFHAALRNSPVNTKNQAVKE RAQGVVLKVLTNFKSSEIEQAVQSL DRNGVDLLMKYIYKGFEKPTENSSA VLLQWHEKALAVGGLGSIIRVLTAR KTV
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ARPC5L actin related protein 2/3 complex subunit 5 like [ Homo sapiens (human) ]
• Official Symbol: ARPC5L
• Synonyms: ARPC5L; actin related protein 2/3 complex subunit 5 like; ARC16-2; actin-related protein 2/3 complex subunit 5-like protein; arp2/3 complex 16 kDa subunit 2
• Gene ID: 81873
• mRNA Refseq: NM_030978
• Protein Refseq: NP_112240
• UniProt ID: Q9BPX5

Reviews

07/18/2021

The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.

06/25/2021

In addition to its outstanding quality, the manufacturer of the ARPC5L protein provides excellent technical support, which is a valuable asset for researchers

01/13/2021

The ARPC5L protein is of exceptional quality, making it an ideal choice to meet my experimental requirements.

Q&As

Is ARPC5L protein ubiquitously expressed in all cell types?

ARPC5L expression has been observed in a wide range of tissues and cell types, suggesting it is likely expressed ubiquitously. Nonetheless, its expression levels may vary depending on the cell type or tissue and can be regulated in a context-specific manner.

Can ARPC5L depletion or disruption result in cellular abnormalities?

Yes, ARPC5L depletion or disruption can lead to cellular abnormalities. Impaired actin cytoskeleton regulation, caused by ARPC5L dysfunction, can affect various cellular processes such as cell shape, migration, and division.

Does ARPC5L have any role in neuronal development or synaptic plasticity?

There is evidence suggesting that ARPC5L is involved in neuronal development and synaptic plasticity. It participates in the formation of dendritic spines, which are essential for synaptic connections and neuronal communication.

Are there any known drugs that target ARPC5L or the ARP2/3 complex?

Currently, there are no specific drugs available that directly target ARPC5L or the ARP2/3 complex. However, various small molecules and compounds that indirectly modulate actin dynamics are under investigation for their potential in therapeutics targeting Actin-related processes.

Are there any known interacting proteins or complexes with ARPC5L?

ARPC5L interacts with various proteins and complexes involved in actin dynamics and cell signaling. Some of the known interacting partners include other subunits of the ARP2/3 complex, actin-binding proteins, signaling molecules like Rho GTPases, and adaptor proteins involved in membrane trafficking.

Is ARPC5L involved in cytokinesis?

Yes, ARPC5L plays a role in cytokinesis, the process of cell division. It helps in the formation of the actin-based contractile ring, which drives the separation of daughter cells during cytokinesis.

Are there any known genetic disorders associated with ARPC5L mutations?

Currently, there are no known specific genetic disorders directly attributed to ARPC5L mutations. However, abnormalities in actin cytoskeleton regulation, which ARPC5L is involved in, can contribute to various developmental and disease-related phenotypes.