Recombinant Human ARSG, His-tagged

• Cat.No.: ARSG-7103H
• Product Overview: Recombinant human ARSG protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: ARSG belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 57kDa (532aa)
• Protein length: 17-525aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSGFLYPLV DFCISGKTRG QKPNFVIILA DDMGWGDLGA NWAETKDTAN LDKMASEGMR FVDFHAAAST CSPSRASLLT GRLGLRNGVT RNFAVTSVGG LPLNETTLAE VLQQAGYVTG IIGKWHLGHH GSYHPNFRGF DYYFGIPYSH DMGCTDTPGY NHPPCPACPQ GDGPSRNLQR DCYTDVALPL YENLNIVEQP VNLSSLAQKY AEKATQFIQR ASTSGRPFLL YVALAHMHVP LPVTQLPAAPRGRSLYGAGL WEMDSLVGQI KDKVDHTVKE NTFLWFTGDN GPWAQKCELA GSVGPFTGFW QTRQGGSPAK QTTWEGGHRV PALAYWPGRV PVNVTSTALL SVLDIFPTVV ALAQASLPQG RRFDGVDVSE VLFGRSQPGH RVLFHPNSGA AGEFGALQTV RLERYKAFYI TGGARACDGSTGPELQHKFP LIFNLEDDTA EAVPLERGGA EYQAVLPEVR KVLADVLQDI ANDNISSADY TQDPSVTPCC NPYQIACRCQ AA
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: ARSG arylsulfatase G [ Homo sapiens ]
• Official Symbol: ARSG
• Synonyms: ARSG; arylsulfatase G; KIAA1001; ASG
• Gene ID: 22901
• mRNA Refseq: NM_014960
• Protein Refseq: NP_055775
• MIM: 610008
• UniProt ID: Q96EG1
• Chromosome Location: 17q24
• Pathway: Lysosome, organism-specific biosystem; Lysosome, conserved biosystem
• Function: arylsulfatase activity; NOT arylsulfatase activity; arylsulfatase activity; hydrolase activity; metal ion binding

Reviews

07/26/2017

Its superior purity and stability ensure reliable and reproducible results, providing me with confidence in the integrity of my experiments.

06/20/2017

Whether I am investigating protein-protein interactions, studying enzymatic activity, or conducting protein structure analyses, the ARSG protein consistently delivers exceptional performance and accurate results.

02/03/2016

The ARSG protein is an exceptional product that meets the highest standards of quality, making it an ideal choice to fulfill my experimental requirements.

Q&As

Are there any diseases associated with mutations in the ARSG gene?

Currently, there are no known diseases directly associated with mutations in the ARSG gene. Further research is needed to determine if any mutations in this gene can cause specific health conditions.

Can ARSG be used as a therapeutic target?

Currently, there are no therapeutic strategies directly targeting ARSG due to limited knowledge of its function and disease associations. However, further research on its role in sulfated molecule metabolism may identify potential therapeutic applications in the future.

Is there any evidence linking ARSG to cancer?

There is limited scientific evidence linking ARSG to cancer. However, some studies have indicated its altered expression in certain cancer types, suggesting a potential association. Further research is necessary to understand the significance of ARSG in cancer development and progression.

Are there any known interacting proteins or pathways associated with ARSG?

The specific interacting proteins or pathways associated with ARSG are currently not well-established. Further research is required to understand its potential interactions and pathways in cellular processes.

Are there any known genetic variations in the ARSG gene?

Yes, genetic variations or single nucleotide polymorphisms (SNPs) have been identified in the ARSG gene. These variations may have implications for protein function, but their exact significance and impact on health are not yet fully understood.

Is there any ongoing research in relation to the ARSG protein?

While research on the ARSG protein is limited, ongoing studies aim to elucidate its biological function, substrate specificity, and potential roles in various cellular processes. Additionally, investigations may focus on understanding the consequences of ARSG mutations and exploring therapeutic strategies for related diseases, if any are identified in the future.