Recombinant Human ASB10 protein, GST-tagged

• Cat.No.: ASB10-883H
• Product Overview: Human ASB10 full-length ORF ( ADR83186.1, 1 a.a. - 467 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 51.4 kDa
• AA Sequence: MLMSWSPEECKGQGEPLDDRHPLCA RLVEKPSRGSEEHLKSGPGPIVTRT ASGPALAFWQAVLAGDVGCVSRILA DSSTGLAPDSVFDTSDPERWRDFRF NIRALRLWSLTYEEELTTPLHVAAS RGHTEVLRLLLRRRARPDSAPGGRT ALHEACAAGHTACVHVLLVAGADPN IADQDGKRPLHLCRGPGTLECAELL LRFGARVDGRSEEEEETPLHVAARL GHVELADLLLRRGACPDARNAEGWT PLLAACDVRCQSITDAEATTARCLQ LCSLLLSAGADADAADQDKQRPLHL ACRRGHAAVVELLLSCGVSANTMDY GGHTPLHCALQGPAAALAQSPEHVV RALLNHGAVRVWPGALPKVLERWST CPRTIEVLMNTYSVVQLPEEAVGLV TPETLQKHQRFYSSLFALVRQPRSL QHLSRCALRSHLEGSLPQALPRLPL PPRLLRYLQLDFEGVLY
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASB10 ankyrin repeat and SOCS box containing 10 [ Homo sapiens ]
• Official Symbol: ASB10
• Synonyms: ASB10; ankyrin repeat and SOCS box containing 10; ankyrin repeat and SOCS box protein 10
• Gene ID: 136371
• mRNA Refseq: NM_001142459
• Protein Refseq: NP_001135931
• UniProt ID: Q8WXI3

Reviews

04/14/2020

From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the ASB10 protein in the format and specifications required for their particular studies.

01/03/2020

the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

08/24/2017

Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

Q&As

Is ASB10 involved in neuronal development?

ASB10 has been suggested to play a role in neuronal development and maturation, possibly by regulating the abundance of specific proteins involved in these processes.

Is ASB10 expressed in other tissues besides the brain?

While ASB10 expression is highest in the brain, it has also been detected in low levels in other tissues like the heart, testis, and skeletal muscle.

Does ASB10 have any association with neurological disorders?

ASB10 has been implicated in neurological disorders, with some studies suggesting its involvement in autism spectrum disorders and cognitive impairments.

Can ASB10 be involved in protein quality control?

ASB10's participation in protein quality control mechanisms, such as targeting misfolded or aggregated proteins for degradation, remains speculative and requires further investigation.

Can ASB10 modulate synaptic plasticity?

ASB10 has been implicated in the regulation of synaptic plasticity, which is crucial for learning and memory formation, suggesting its potential involvement in cognitive processes.

Does ASB10 play a role in neurodegeneration?

The involvement of ASB10 in neurodegenerative diseases, such as Alzheimer's and Parkinson's, has not been extensively studied, and more research is needed to establish any associations.

Can ASB10 interact with other proteins?

Yes, ASB10 can interact with various proteins through its ankyrin repeat domain, potentially influencing protein degradation and cellular signaling.