Recombinant Human ASB3 protein, GST-tagged

• Cat.No.: ASB3-892H
• Product Overview: Human ASB3 full-length ORF ( AAH06488.1, 1 a.a. - 518 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 82.72 kDa
• AA Sequence: MDFTEAYADTCSTVGLAAREGNVKV LRKLLKKGRSVDVADNRGWMPIHEA AYHNSVECLQMLINADSSENYIKMK TFEGFCALHLAASQGHWKIVQILLE AGADPNATTLEETTPLFLAVENGQI DVLRLLLQHGANVNGSHSMCGWNSL HQASFQENAEIIKLLLRKGANKECQ DDFGITPLFVAAQYGKLESLSILIS SGANVNCQALDKATPLFIAAQEGHT KCVELLLSSGADPDLYCNEDSWQLP IHAAAQMGHTKILDLLIPLTNRACD TGLNKVSPVYSAVFGGHEDCLEILL RNGYSPDAQACLVFGFSSPVCMAFQ KDCEFFGIVNILLKYGAQINELHLA YCLKYEKFSIFRYFLRKGCSLGPWN HIYEFVNHAIKAQAKYKEWLPHLLV AGFDPLILLCNSWIDSVSIDTPIFT LEFTNWKTLAPAVERMLSARASNAW ILQQHIATVPSLTHLCRLEIRSSLK SERLRSDSYISQLPLPRSLHNYLLY EDVLRMYEVPELAAIQDG
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASB3 ankyrin repeat and SOCS box containing 3 [ Homo sapiens ]
• Official Symbol: ASB3
• Synonyms: ASB3; ankyrin repeat and SOCS box containing 3; ankyrin repeat and SOCS box protein 3; ASB 3; ASB-3
• Gene ID: 51130
• mRNA Refseq: NM_001201965
• Protein Refseq: NP_001188894
• MIM: 605760
• UniProt ID: Q9Y575

Reviews

12/05/2022

Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

10/13/2016

With the ASB3 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

06/06/2016

Its exceptional properties and reliable results make it a valuable tool in various experimental applications.

Q&As

Are there any known interactions of the ASB3 protein with other proteins?

Yes, ASB3 has been shown to interact with several proteins, including Cullin 5, Elongin BC complex, and the E3 ubiquitin ligase complex, among others.

Does ASB3 have any known substrates for protein degradation?

ASB3 has been reported to target proteins such as Notch1, Smurf1, and Fanconi anemia-associated protein FANCC for ubiquitination and subsequent degradation.

Is ASB3 involved in any specific cellular pathways or processes?

ASB3 is involved in regulating various pathways, including the Notch signaling pathway, TGF-β signaling pathway, and Wnt/β-catenin signaling pathway, among others.

Are there any known small molecules or drugs that can modulate ASB3 activity?

Currently, there are no known small molecules or drugs specifically targeting ASB3 activity, but further research may unveil potential therapeutic interventions.

Are there any genetic variations or polymorphisms in the ASB3 gene?

Yes, various genetic variations and polymorphisms in the ASB3 gene have been identified, some of which have been associated with certain diseases and conditions.

Can mutations in the ASB3 gene lead to any disorders?

Mutations in the ASB3 gene have been found in individuals with intellectual disability and developmental delay, suggesting a potential role in these disorders.

Is ASB3 expression regulated by environmental factors?

The regulation of ASB3 expression by environmental factors is not well-documented. More research is needed to investigate this aspect.