Recombinant Human ASB5 protein, His-tagged

• Cat.No.: ASB5-2529H
• Product Overview: Recombinant Human ASB5 protein(245-329 aa), fused to His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
• Protein length: 245-329 aa
• AA Sequence: STEIVNLLLEFGADINAKNTELLRP IDVATSSSMVERILLQHEATPSSLY QLCRLCIRSYIGKPRLHLIPQLQLP TLLKNFLQYR
• Purity: 80%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: ASB5 ankyrin repeat and SOCS box containing 5 [ Homo sapiens ]
• Official Symbol: ASB5
• Synonyms: ASB5; ankyrin repeat and SOCS box containing 5; ankyrin repeat and SOCS box protein 5; SOCS box protein ASB-5; ankyrin repeat and SOCS box-containing 5; ASB-5
• Gene ID: 140458
• mRNA Refseq: NM_080874
• Protein Refseq: NP_543150
• UniProt ID: Q8WWX0

Reviews

11/18/2022

Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

09/16/2019

he ASB5 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.

04/09/2016

the ASB5 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.

Q&As

Are there any known binding partners of the ASB5 protein?

ASB5 can interact with different proteins, including ankyrin repeat and SOCS box-containing protein 10 (ASB10), which can modulate ASB5 activity in muscle development.

Are there any known genetic mutations or polymorphisms in the ASB5 gene?

Yes, several genetic variations in the ASB5 gene have been identified. Some of these variations are associated with muscle-related disorders and cardiac abnormalities.

Does ASB5 have a role in neurodevelopment or neurological disorders?

While ASB5's role in neurodevelopment or neurological disorders is not extensively studied, it may play a part in neuronal differentiation and function. Further research is required to determine its implications in neurological conditions.

Can ASB5 be involved in the regulation of muscle development?

Yes, studies have shown that ASB5 is important for muscle development and differentiation, particularly in the formation of skeletal muscle fibers.

Are there any diseases or disorders associated with altered ASB5 expression or function?

Altered ASB5 expression or function has been observed in various conditions, including myopathies, neuropathies, and cardiac diseases. However, further research is needed to fully understand the extent of its involvement in these disorders.

Is ASB5 involved in any other cellular processes or pathways?

While ASB5 is primarily known for its role in muscle development and protein degradation, it may also participate in other processes, such as cell proliferation and differentiation.

Does ASB5 play a role in cardiac function or disease?

Yes, ASB5 has been implicated in cardiac diseases, including dilated cardiomyopathy and heart failure. It may contribute to the degradation of specific proteins involved in cardiac muscle contraction.

Can ASB5 expression be regulated by other factors or signaling pathways?

Yes, ASB5 expression can be regulated by signaling pathways involved in muscle development, such as the Notch signaling pathway.