Recombinant Human ASCL3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ASCL3-3306H
• Product Overview: ASCL3 MS Standard C13 and N15-labeled recombinant protein (NP_065697) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 20.7 kDa
• AA Sequence: MMDNRGNSSLPDKLPIFPDSARLPL TRSFYLEPMVTFHVHPEAPVSSPYS EELPRLPFPSDSLILGNYSEPCPFS FPMPYPNYRGCEYSYGPAFTRKRNE RERQRVKCVNEGYAQLRHHLPEEYL EKRLSKVETLRAAIKYINYLQSLLY PDKAETKNNPGKVSSMIATTSHHAD PMFRIVTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ASCL3 achaete-scute family bHLH transcription factor 3 [ Homo sapiens (human) ]
• Official Symbol: ASCL3
• Synonyms: ASCL3; achaete-scute complex homolog 3 (Drosophila); achaete scute complex (Drosophila) homolog like 3; achaete-scute homolog 3; bHLHa42; HASH3; Sgn1; ASH-3; bHLH transcriptional regulator Sgn-1; class A basic helix-loop-helix protein 42; bHLH transcription factor Sgn-1 (Salivary Glands 1); SGN1
• Gene ID: 56676
• mRNA Refseq: NM_020646
• Protein Refseq: NP_065697
• MIM: 609154
• UniProt ID: Q9NQ33

Reviews

05/12/2022

Choosing the ASCL3 protein from this manufacturer not only provides me with a superior product but also grants me access to unparalleled technical support.

08/08/2021

The manufacturer's extensive experience and expertise in the field of ASCL3 protein research make them a trusted partner.

10/02/2016

The manufacturer's commitment to customer satisfaction and their willingness to customize solutions based on specific experimental requirements is commendable.

Q&As

Is ASCL3 involved in embryonic development?

Yes, ASCL3 has been shown to play a role in embryonic development, particularly in the formation of the gastrointestinal tract.

Can ASCL3 be used as a diagnostic marker for gastrointestinal diseases?

ASCL3 expression and its dysregulation have been proposed as potential diagnostic markers for certain gastrointestinal diseases. However, further research is needed to establish its clinical utility.

What are the molecular functions of ASCL3?

ASCL3 acts as a transcription factor, binding to specific DNA sequences in the genome and regulating the expression of target genes involved in cellular differentiation and development.

What happens when ASCL3 is mutated or dysregulated?

Mutations or dysregulation of ASCL3 can lead to various gastrointestinal diseases, including colorectal cancer and inflammatory bowel diseases.

Does ASCL3 interact with other proteins?

Yes, ASCL3 can interact with several other proteins to regulate its activity and downstream signaling pathways. Some known interacting proteins include β-catenin, SMAD4, and p300.