Recombinant Human ASCL4, GST-tagged

• Cat.No.: ASCL4-9927H
• Product Overview: Recombinant Human ASCL4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-70a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ASCL4 achaete-scute complex homolog 4 (Drosophila) [ Homo sapiens ]
• Official Symbol: ASCL4
• Synonyms: ASCL4; achaete-scute complex homolog 4 (Drosophila); achaete scute complex like 4 (Drosophila); achaete-scute homolog 4; bHLHa44; HASH4; ASH-4; class II bHLH protein ASCL4; achaete-scute complex-like 4; achaete-scute-like protein 4; class A basic helix-loop-helix protein 44
• Gene ID: 121549
• mRNA Refseq: NM_203436
• Protein Refseq: NP_982260
• MIM: 609155
• UniProt ID: Q6XD76
• Chromosome Location: 12q24.11
• Function: DNA binding

Reviews

08/12/2020

They understand that each research project may have unique requirements, and they are more than willing to address these specific needs.

11/29/2019

The manufacturer's commitment to customer satisfaction is unmatched.

09/18/2019

Their prompt and insightful responses to inquiries and troubleshooting requests enable me to tackle experimental obstacles with confidence and efficiency.

Q&As

Does ASCL4 interact with other proteins?

Yes, ASCL4 can interact with several other proteins to regulate its activity and downstream signaling pathways. Some known interacting proteins include Groucho/TLE family members and histone deacetylases.

Can ASCL4 be targeted for therapeutic purposes?

While ASCL4 shows promise as a potential therapeutic target for neurological disorders, more research is needed to investigate its mechanisms of action and the potential consequences of manipulating its activity.

What are the molecular functions of ASCL4?

ASCL4 acts as a transcription factor, binding to specific DNA sequences in the genome and regulating the expression of target genes involved in neuronal development and differentiation.

Is ASCL4 involved in any diseases?

Currently, there is limited knowledge about the involvement of ASCL4 in diseases. More research is needed to understand its potential role in neurological disorders.