Recombinant Human ASL protein, GST-tagged

• Cat.No.: ASL-909H
• Product Overview: Human ASL full-length ORF ( AAH08195, 1 a.a. - 464 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 76.78 kDa
• AA Sequence: MASESGKLWGGRFVGAVDPIMEKFN ASIAYDRHLWEVDVQGSKAYSRGLE KAGLLTKAEMDQILHGLDKVAEEWA QGTFKLNSNDEDIHTANERRLKELI GATAGKLHTGRSRNDQVVTDLRLWM RQTCSTLSGLLWELIRTMVDRAEAE RDVLFPGYTHLQRAQPIRWSHWILS HAVALTRDSERLLEVRKRINVLPLG SGAIAGNPLGVDRELLRAELNFGAI TLNSMDATSERDFVAELLFWASLCM THLSRMAEDLILYCTKEFSFVQPSD AYSTGSSLMPQKKNPDSLELIRSKA GRVFGRCAGLLMTLKGLPSTYNKDL QEDKEAVFEVSDTMSAVLQVATGVI STLQIHQENMGQALSPDMLATDLAY YLVRKGMPFRQAHEASGKAVFMAET KGVALNQLSLQELQTISPLFSGDVI CVWDYGHSVEQYGALGGTARSSVDW QIRQVRALLQAQQA
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASL argininosuccinate lyase [ Homo sapiens ]
• Official Symbol: ASL
• Synonyms: ASL; argininosuccinate lyase; arginosuccinase; argininosuccinase; ASAL
• Gene ID: 435
• mRNA Refseq: NM_000048
• Protein Refseq: NP_000039
• MIM: 608310
• UniProt ID: P04424