Recombinant Human ATF4 protein, GST-tagged

• Cat.No.: ATF4-939H
• Product Overview: Human ATF4 full-length ORF ( AAH08090, 1 a.a. - 351 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 64.35 kDa
• AA Sequence: MTEMSFLSSEVLVGDLMSPFDPSGL GAEESLGLLDDYLEVAKHFKPHGFS SDKAKAGSSEWLAVDGLVSPSNNSK EDAFSGTDWMLEKMDLKEFDLDALL GIDDLETMPDDLLTTLDDTCDLFAP LVQETNKQPPQTVNPIGHLPESLTK PDQVAPFTFLQPPPLSPGVLSSTPD HSFSLELGSEVDITEGDRKPDYTAY VAMIPQCIKEEDTPSDNDSGICMSP ESYLGSPQHSPSTRGSPNRSLPSPG VLCGSARPKPYDPPGEKMVAAKVKG EKLDKKLKKMEQNKTAATRYRQKKR AEQEALTGECKELEKKNEALKERAD SLAKEIQYLKDLIEEVRKARGKKRV P
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) [ Homo sapiens ]
• Official Symbol: ATF4
• Synonyms: ATF4; activating transcription factor 4 (tax-responsive enhancer element B67); TXREB; cyclic AMP-dependent transcription factor ATF-4; CREB 2; TAXREB67; DNA-binding protein TAXREB67; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; cyclic AMP-responsive element-binding protein 2; tax-responsive enhancer element-binding protein 67; CREB2; CREB-2
• Gene ID: 468
• mRNA Refseq: NM_001675
• Protein Refseq: NP_001666
• MIM: 604064
• UniProt ID: P18848