Recombinant Human ATF6B
Cat.No. : | ATF6B-26189TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 2-88 of Human ATF6 beta, with an N-terminal proprietary tag, predicted MWt 35.2 kDa |
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Description : | The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. |
Protein length : | 87 amino acids |
Molecular Weight : | 35.200kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Ubiquitous. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | AELMLLSEIADPTRFFTDNLLSPED WGLQNSTLYSGLDEVAEEQTQLFRC PEQDVPFDGSSLDVGMDVSPSEPPW ELLPIFPDLQVK |
Sequence Similarities : | Belongs to the bZIP family. ATF subfamily.Contains 1 bZIP domain. |
Gene Name : | ATF6B activating transcription factor 6 beta [ Homo sapiens ] |
Official Symbol : | ATF6B |
Synonyms : | ATF6B; activating transcription factor 6 beta; cAMP responsive element binding protein like 1 , CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta; G13; |
Gene ID : | 1388 |
mRNA Refseq : | NM_001136153 |
Protein Refseq : | NP_001129625 |
MIM : | 600984 |
Uniprot ID : | Q99941 |
Chromosome Location : | 6p21.3 |
Pathway : | Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G1 to S cell cycle control, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; |
Function : | protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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