Recombinant Human ATP2B4
Cat.No. : | ATP2B4-27795TH |
Product Overview : | Recombinant fragment of Human Calcium Pump PMCA4 ATPase with a N terminal proprietary tag: predicted molecular weight 35.75 kDa. |
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Description : | The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Protein length : | 92 amino acids |
Molecular Weight : | 35.750kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MTNPSDRVLPANSMAESREGDFGCT VMELRKLMELRSRDALTQINVHYGG VQNLCSRLKTSPVEGLSGNPADLEK RRQVFGHNVIPPKKPKT* |
Sequence Similarities : | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. |
Gene Name : | ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 [ Homo sapiens ] |
Official Symbol : | ATP2B4 |
Synonyms : | ATP2B4; ATPase, Ca++ transporting, plasma membrane 4; ATP2B2, matrix remodelling associated 1 , MXRA1; plasma membrane calcium-transporting ATPase 4; plasma membrane calcium transporting ATPase 4; PMCA4; |
Gene ID : | 493 |
mRNA Refseq : | NM_001001396 |
Protein Refseq : | NP_001001396 |
MIM : | 108732 |
Uniprot ID : | P23634 |
Chromosome Location : | 1q32.1 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Hemostasis, organism-specific biosystem; Ion channel transport, organism-specific biosystem; |
Function : | ATP binding; PDZ domain binding; calcium-transporting ATPase activity; calmodulin binding; hydrolase activity; |
Products Types
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ATP2B4-2945H | Recombinant Human ATP2B4 Protein, MYC/DDK-tagged | +Inquiry |
ATP2B4-280R | Recombinant Rhesus Macaque ATP2B4 Protein, His (Fc)-Avi-tagged | +Inquiry |
ATP2B4-301117H | Recombinant Human ATP2B4 protein, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionATP2B4 gene mutation may be related to some hereditary diseases such as acoustic neuroma and lung cancer.
This is a calcium transporter, which is mainly responsible for transporting intracellular calcium to the outside of the cell, thereby maintaining the intracellular and extracellular calcium balance.
There are several differences in protein structure and function between ATP2B4 and other atpase B family members, mainly depending on how they are expressed and regulated in different tissues and cells.
The production pathway of ATP2B4 protein mainly includes multiple biological processes such as gene transcription, RNA splicing, protein translation and subsequent modification.
The expression of ATP2B4 may be related to the occurrence and development of diabetes, obesity, cardiovascular disease, liver disease and other diseases.
The relationship between ATP2B4 and cardiovascular disease may be achieved through several mechanisms such as regulating cardiomyocyte contraction and vascular smooth muscle cell contraction.
Customer Reviews (3)
Write a reviewBecause it is not easy to be contaminated, it is stored again.
The protein's activity is truly remarkable, able to catalyze reactions even under extreme conditions.
ATP2B4's stability is truly remarkable, able to maintain its activity even under extreme conditions.
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