Recombinant Human ATP7B Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | ATP7B-3895H |
Product Overview : | ATP7B MS Standard C13 and N15-labeled recombinant protein (NP_000044) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 157.1 kDa |
AA Sequence : | MPEQERQITAREGASRKILSKLSLP TRAWEPAMKKSFAFDNVGYEGGLDG LGPSSQVATSTVRILGMTCQSCVKS IEDRISNLKGIISMKVSLEQGSATV KYVPSVVCLQQVCHQIGDMGFEASI AEGKAASWPSRSLPAQEAVVKLRVE GMTCQSCVSSIEGKVRKLQGVVRVK VSLSNQEAVITYQPYLIQPEDLRDH VNDMGFEAAIKSKVAPLSLGPIDIE RLQSTNPKRPLSSANQNFNNSETLG HQGSHVVTLQLRIDGMHCKSCVLNI EENIGQLLGVQSIQVSLENKTAQVK YDPSCTSPVALQRAIEALPPGNFKV SLPDGAEGSGTDHRSSSSHSPGSPP RNQVQGTCSTTLIAIAGMTCASCVH SIEGMISQLEGVQQISVSLAEGTAT VLYNPAVISPEELRAAIEDMGFEAS VVSESCSTNPLGNHSAGNSMVQTTD GTPTSLQEVAPHTGRLPANHAPDIL AKSPQSTRAVAPQKCFLQIKGMTCA SCVSNIERNLQKEAGVLSVLVALMA GKAEIKYDPEVIQPLEIAQFIQDLG FEAAVMEDYAGSDGNIELTITGMTC ASCVHNIESKLTRTNGITYASVALA TSKALVKFDPEIIGPRDIIKIIEEI GFHASLAQRNPNAHHLDHKMEIKQW KKSFLCSLVFGIPVMALMIYMLIPS NEPHQSMVLDHNIIPGLSILNLIFF ILCTFVQLLGGWYFYVQAYKSLRHR SANMDVLIVLATSIAYVYSLVILVV AVAEKAERSPVTFFDTPPMLFVFIA LGRWLEHLAKSKTSEALAKLMSLQA TEATVVTLGEDNLIIREEQVPMELV QRGDIVRVVPGGKFPVDGKVLEGNT MADESLITGEAMPVTKKPGSTVIAG SINAHGSVLIKATHVGNDTTLAQIV KLVEEAQMSKAPIQQLADRFSGYFV PFIIIMSTLTLVVWIVIGFIDFGVV QKYFPNPNKHISQTEVIIRFAFQTS ITVLCIACPCSLGLATPTAVMVGTG VAAQNGILIKGGKPLEMAHKIKTVM FDKTGTITHGVPRVMRVLLLGDVAT LPLRKVLAVVGTAEASSEHPLGVAV TKYCKEELGTETLGYCTDFQAVPGC GIGCKVSNVEGILAHSERPLSAPAS HLNEAGSLPAEKDAAPQTFSVLIGN REWLRRNGLTISSDVSDAMTDHEMK GQTAILVAIDGVLCGMIAIADAVKQ EAALAVHTLQSMGVDVVLITGDNRK TARAIATQVGINKVFAEVLPSHKVA KVQELQNKGKKVAMVGDGVNDSPAL AQADMGVAIGTGTDVAIEAADVVLI RNDLLDVVASIHLSKRTVRRIRINL VLALIYNLVGIPIAAGVFMPIGIVL QPWMGSAAMAASSVSVVLSSLQLKC YKKPDLERYEAQAHGHMKPLTASQV SVHIGMDDRWRDSPRATPWDQVSYV SQVSLSSLTSDKPSRHSAAADDDGD KWSLLLNGRDEEQYITRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | ATP7B ATPase copper transporting beta [ Homo sapiens (human) ] |
Official Symbol : | ATP7B |
Synonyms : | ATP7B; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (Wilson disease), WND; copper-transporting ATPase 2; Wilson disease; copper pump 2; Wilson disease-associated protein; ATPase, Cu(2+)- transporting, beta polypeptide; WD; PWD; WC1; WND; |
Gene ID : | 540 |
mRNA Refseq : | NM_000053 |
Protein Refseq : | NP_000044 |
MIM : | 606882 |
UniProt ID : | P35670 |
Products Types
◆ Recombinant Protein | ||
Atp7b-676M | Recombinant Mouse Atp7b Protein, MYC/DDK-tagged | +Inquiry |
ATP7B-885M | Recombinant Mouse ATP7B Protein, His (Fc)-Avi-tagged | +Inquiry |
Atp7b-275M | Recombinant Mouse Atp7b Protein, His-tagged | +Inquiry |
ATP7B-468H | Recombinant Human ATP7B Protein, Myc/ddk-tagged | +Inquiry |
ATP7B-467H | Recombinant Human ATP7B Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ATP7B-8572HCL | Recombinant Human ATP7B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionATP7B facilitates copper transport from the cytoplasm to the Golgi apparatus, where copper is incorporated into proteins. It also mediates copper export from cells when copper levels are elevated, preventing toxicity.
ATP7B interacts with various proteins in the copper transport pathway. Disruptions in these interactions can lead to mislocalization of ATP7B and compromise its ability to regulate copper levels properly.
ATP7B ensures the proper supply of copper to enzymes involved in various cellular processes, including energy production and antioxidant defense. Dysregulation can disrupt these processes, affecting cell function.
ATP7B is crucial for copper excretion into bile, a process that contributes to systemic copper balance. Dysfunctional ATP7B results in impaired copper excretion, leading to the accumulation of copper in tissues.
Mutations in the ATP7B gene lead to impaired copper transport, causing copper accumulation in tissues. This is associated with Wilson's disease, a disorder characterized by copper toxicity, especially in the liver and brain.
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Write a reviewImpressed with the product quality.
The product exceeded expectations.
This product consistently delivers accurate results in our experiments.
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