Recombinant Human ATRN Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ATRN-5517H
• Product Overview: ATRN MS Standard C13 and N15-labeled recombinant protein (NP_647538) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 141.4 kDa
• AA Sequence: MVAAAAATEARLRRRTAATAALAGR SGGPHWDWDVTRAGRPGLGAGLRLP RLLSPPLRPRLLLLLLLLSPPLLLL LLPCEAEAAAAAAAVSGSAAAEAKE CDRPCVNGGRCNPGTGQCVCPAGWV GEQCQHCGGRFRLTGSSGFVTDGPG NYKYKTKCTWLIEGQPNRIMRLRFN HFATECSWDHLYVYDGDSIYAPLVA AFSGLIVPERDGNETVPEVVATSGY ALLHFFSDAAYNLTGFNITYSFDMC PNNCSGRGECKISNSSDTVECECSE NWKGEACDIPHCTDNCGFPHRGICN SSDVRGCSCFSDWQGPGCSVPVPAN QSFWTREEYSNLKLPRASHKAVVNG NIMWVVGGYMFNHSDYNMVLAYDLA SREWLPLNRSVNNVVVRYGHSLALY KDKIYMYGGKIDSTGNVTNELRVFH IHNESWVLLTPKAKEQYAVVGHSAH IVTLKNGRVVMLVIFGHCPLYGYIS NVQEYDLDKNTWSILHTQGALVQGG YGHSSVYDHRTRALYVHGGYKAFSA NKYRLADDLYRYDVDTQMWTILKDS RFFRYLHTAVIVSGTMLVFGGNTHN DTSMSHGAKCFSSDFMAYDIACDRW SVLPRPDLHHDVNRFGHSAVLHNST MYVFGGFNSLLLSDILVFTSEQCDA HRSEAACLAAGPGIRCVWNTGSSQC ISWALATDEQEEKLKSECFSKRTLD HDRCDQHTDCYSCTANTNDCHWCND HCVPRNHSCSEGQISIFRYENCPKD NPMYYCNKKTSCRSCALDQNCQWEP RNQECIALPENICGIGWHLVGNSCL KITTAKENYDNAKLFCRNHNALLAS LTTQKKVEFVLKQLRIMQSSQSMSK LTLTPWVGLRKINVSYWCWEDMSPF TNSLLQWMPSEPSDAGFCGILSEPS TRGLKAATCINPLNGSVCERPANHS AKQCRTPCALRTACGDCTSGSSECM WCSNMKQCVDSNAYVASFPFGQCME WYTMSTCPPENCSGYCTCSHCLEQP GCGWCTDPSNTGKGKCIEGSYKGPV KMPSQAPTGNFYPQPLLNSSMCLED SRYNWSFIHCPACQCNGHSKCINQS ICEKCENLTTGKHCETCISGFYGDP TNGGKCQPCKCNGHASLCNTNTGKC FCTTKGVKGDECQLCEVENRYQGNP LRGTCYYTLLIDYQFTFSLSQEDDR YYTAINFVATPDEQNRDLDMFINAS KNFNLNITWAASFSAGTQAGEEMPV VSKTNIKEYKDSFSNEKFDFRNHPN ITFFVYVSNFTWPIKIQVQTEQSGP TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ATRN attractin [ Homo sapiens (human) ]
• Official Symbol: ATRN
• Synonyms: ATRN; attractin; DPPT L; mahogany protein; MGCA; attractin-2; mahogany homolog; DPPT-L; KIAA0548; MGC126754
• Gene ID: 8455
• mRNA Refseq: NM_139322
• Protein Refseq: NP_647538
• MIM: 603130
• UniProt ID: O75882

Reviews

11/13/2022

ATRN's exceptional purity ensures accurate and reproducible experimental results.

07/07/2022

The protein manufacturer's products are backed by strong scientific research and development to provide customers with cutting-edge solutions.

03/04/2022

Because ATRN is resistant to degradation and its stability under various experimental conditions makes it the best choice for Western blot analysis.

Q&As

What diseases or symptoms can be caused by ATRN mutations?

ATRN gene mutations may lead to hereditary hemorrhagic telangiectasia and other diseases. The main features of the disease include telangiectasia on the skin and mucosa, epistaxis, and bleeding in internal organs.

Are there other genes that interact with the ATRN gene?

Yes, the ATRN gene may interact with other genes involved in the regulation of cell development and function, such as the Netrin-1 gene in nervous system development. These interactions may affect the function and regulatory network of ATRN genes.

Is the ATRN gene regulated?

Yes, ATRN gene expression is affected by a variety of regulatory factors, including binding of transcription factors, activation of signaling pathways, etc. These regulatory mechanisms ensure the adaptability and stability of the ATRN gene.

Is ATRN gene associated with cancer?

At present, no direct association between ATRN gene and cancer has been found. However, the regulatory role of ATRN genes in cell proliferation and differentiation may be indirectly related to tumorigenesis and progression.

What is the expression pattern of ATRN gene?

The ATRN gene is widely expressed in the human body, but its expression level may vary in different tissues and organs. Its expression is higher in brain, retina, kidney and other tissues.

What progress has been made in the research of ATRN gene?

The research on ATRN gene mainly focuses on the analysis of its structure and function, the exploration of its regulatory mechanism, and the relationship with genetic diseases. So far, several important findings have been made regarding the function and regulation of ATRN genes.