Recombinant Human ATXN7 protein, GST-tagged

• Cat.No.: ATXN7-301504H
• Product Overview: Recombinant Human ATXN7 (170-335 aa) protein, fused to GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization.
• Protein length: Met170-Arg335
• AA Sequence: MHSSSSKPPLAVPPTSVFSFFPSLS KSKGGSASGSNRSSSGGVLSASSSS SKLLKSPKEKLQLRGNTRPMHPIQQ SRVPHGRIMTPSVKVEKIHPKMDGT LLKSAVGPTCPATVSSLVKPGLNCP SIPKPTLPSPGQILNGKGLPAPPTL EKKPEDNSNNRKFLNKR
• Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Stability: Store for up to 12 months at -20°C to -80°C as lyophilized powder.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.

Gene Information

• Gene Name: ATXN7 ataxin 7 [ Homo sapiens ]
• Official Symbol: ATXN7
• Synonyms: ATXN7; ataxin 7; SCA7, spinocerebellar ataxia 7 (olivopontocerebellar atrophy with retinal degeneration); ataxin-7; ADCAII; OPCA3; spinocerebellar ataxia type 7 protein; SCA7; FLJ17787
• Gene ID: 6314
• mRNA Refseq: NM_000333
• Protein Refseq: NP_000324
• MIM: 607640
• UniProt ID: O15265

Reviews

04/26/2022

Because the extraordinary stability of ATXN7 under various conditions highlights its robustness and versatility.

02/03/2021

Application range of ATXN7 is really wide, from the laboratory to the clinic, can see its figure, it is really rare.

01/27/2019

This powerful biological activity of proteins combined with their high purity makes their experimental results extremely reliable, which is of great significance in the field of scientific research.

Q&As

What are the structural features of ATXN7 protein?

The ATXN7 protein consists of multiple functional domains, including multiple HEAT repeats, which may be involved in protein interactions and regulation of function.

How about the cellular localization of ATXN7 protein?

ATXN7 protein is mainly located in the nucleus and participates in the regulation of gene transcription.

What is the regulatory mechanism of ATXN7 protein?

The expression and function of ATXN7 protein are affected by multiple regulatory mechanisms, including transcriptional regulation, post-translational modification, and protein-protein interaction.

What are the implications of ATXN7 protein research for disease treatment?

In-depth study of the function and regulatory mechanism of ATXN7 protein will help to reveal the mechanism of spinocerebellar ataxia (SCA7) and provide new targets and strategies for the diagnosis and treatment of the disease.

Which diseases are associated with ATXN7 protein mutations?

The protein mutations are associated with the development of spinocerebellar ataxia (SCA7).

How does the ATXN7 protein interact with other proteins?

ATXN7 protein interacts with multiple proteins, including transcription factors, coactivators, and other regulatory proteins.