Recombinant Human AURKB
Cat.No. : | AURKB-26601TH |
Product Overview : | Recombinant fusion protein, full length human Aurora B expressed by baculovirus in Sf9 insect cells using an N-terminal proprietary tag. |
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Description : | Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al. |
Tissue specificity : | High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain. |
Gene Name : | AURKB aurora kinase B [ Homo sapiens ] |
Official Symbol : | AURKB |
Synonyms : | AURKB; aurora kinase B; serine/threonine kinase 12 , STK12; Aik2; AIM 1; ARK2; AurB; aurora 1; aurora B; IPL1; PPP1R48; protein phosphatase 1; regulatory subunit 48; STK5; |
Gene ID : | 9212 |
mRNA Refseq : | NM_004217 |
Protein Refseq : | NP_004208 |
MIM : | 604970 |
Uniprot ID : | Q96GD4 |
Chromosome Location : | 17p13.1 |
Pathway : | APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Aurora A signaling, organism-specific biosystem; Aurora B signaling, organism-specific biosystem; Aurora C signaling, organism-specific biosystem; |
Function : | ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
AURKB-1112H | Recombinant Human AURKB Protein (A2-A344), Tag Free | +Inquiry |
AURKB-560R | Recombinant Rat AURKB Protein, His (Fc)-Avi-tagged | +Inquiry |
AURKB-909M | Recombinant Mouse AURKB Protein, His (Fc)-Avi-tagged | +Inquiry |
Aurkb-279R | Recombinant Rat Aurkb Protein, His-tagged | +Inquiry |
AURKB-1113H | Recombinant Human AURKB Protein (A2-A344), GST tagged | +Inquiry |
◆ Lysates | ||
AURKB-8560HCL | Recombinant Human AURKB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAURKB protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, INCENP, Survivin, etc., to regulate the progression of cell mitosis.
The substrates of AURKB include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins. Phosphorylation modification of these substrates regulates chromosome segregation and cell division during mitosis.
AURKB protein is mainly located in the nucleus and cytoplasm and participates in the regulation of cell mitosis.
The expression of the AURKB gene is regulated by cell cycle regulators and other transcription factors and is mainly expressed in the mitotic phase of cells.
The activity of AURKB protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.
The protein reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.
Customer Reviews (3)
Write a reviewAURKB's exceptional repeatability allows for its reliable use in a range of applications, making it a top choice for researchers.
Very pure and can be used with confidence.
The quality is very high and very reliable.
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