Recombinant Human AURKC

• Cat.No.: AURKC-27499TH
• Product Overview: Recombinant full length IPL-1/STK13/Aurora C protein (Human), MW ~61 kDa with N terminal enzyme tag, expressed by baculovirus in Sf9 insect cells.

Specification

• Description: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
• Tissue specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
• Biological activity: Specific activity 65nmol/min/mg
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: AURKC aurora kinase C [ Homo sapiens ]
• Official Symbol: AURKC
• Synonyms: AURKC; aurora kinase C; serine/threonine kinase 13 (aurora/IPL1 like) , STK13; ARK3; AurC
• Gene ID: 6795
• mRNA Refseq: NM_001015878
• Protein Refseq: NP_001015878
• MIM: 603495
• Uniprot ID: Q9UQB9
• Chromosome Location: 19q13.3-qter
• Pathway: Aurora B signaling, organism-specific biosystem; Aurora C signaling, organism-specific biosystem; Signaling by Aurora kinases, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity

Reviews

06/01/2020

It is very stable and can be stored and used for a long time.

12/02/2019

This price is very reasonable and good value for money.

03/18/2019

The activity is very strong and can meet my research needs.

Q&As

What is the role of AURKC protein in germ cell genesis?

AURKC protein plays an important role in germ cell genesis and is involved in the development, maturation and fertilization of sperm and egg.

What is the regulatory mechanism of AURKC protein activity?

The activity of AURKC protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKC protein reach its peak expression?

It reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

How is AURKC protein associated with cancer?

The abnormal expression of AURKC protein in some cancers is associated with the initiation and progression of tumors. Further studies on the mechanism of action of AURKC protein in cancer may contribute to the development of cancer therapy.

What is the cellular localization of AURKC protein?

AURKC protein is mainly localized in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

How is AURKC protein associated with reproductive disorders and infertility?

Mutation or abnormal expression of AURKC protein is associated with reproductive disorders and infertility in both males and females. Studies have found that AURKC gene mutations may lead to abnormal sperm or egg development and dysfunction.