Recombinant Human AURORA C protein, GST-tagged

• Cat.No.: AURORA C-3779H
• Product Overview: Recombinant Human AURORA C fussed with GST tag was expressed in Insect cells.

Specification

• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~61 kDa
• Protein length: full-length
• Applications: Kinase Assay, Western Blot (WB)
• Notes: Small volumes of AURORA C recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap.
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: AURKC aurora kinase C [ Homo sapiens ]
• Official Symbol: AURKC
• Synonyms: AURKC; aurora kinase C; serine/threonine kinase 13 (aurora/IPL1 like) , STK13; ARK3; AurC; ARK-3; aurora 3; aurora-related kinase 3; aurora/IPL1/EG2 protein 2; aurora/IPL1-related kinase 3; serine/threonine-protein kinase 13; serine/threonine-protein kinase aurora-C; serine/threonine kinase 13 (aurora/IPL1-like); AIE2; AIK3; SPGF5; STK13; aurora-C
• Gene ID: 6795
• mRNA Refseq: NM_003160
• Protein Refseq: NP_003151
• MIM: 603495
• UniProt ID: Q9UQB9
• Chromosome Location: 19q13.3-qter
• Pathway: Aurora B signaling, organism-specific biosystem; Aurora C signaling, organism-specific biosystem; Signaling by Aurora kinases, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity

Reviews

06/01/2020

It is very stable and can be stored and used for a long time.

12/02/2019

This price is very reasonable and good value for money.

03/18/2019

The activity is very strong and can meet my research needs.

Q&As

What is the role of AURKC protein in germ cell genesis?

AURKC protein plays an important role in germ cell genesis and is involved in the development, maturation and fertilization of sperm and egg.

What is the regulatory mechanism of AURKC protein activity?

The activity of AURKC protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKC protein reach its peak expression?

It reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

How is AURKC protein associated with cancer?

The abnormal expression of AURKC protein in some cancers is associated with the initiation and progression of tumors. Further studies on the mechanism of action of AURKC protein in cancer may contribute to the development of cancer therapy.

What is the cellular localization of AURKC protein?

AURKC protein is mainly localized in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

How is AURKC protein associated with reproductive disorders and infertility?

Mutation or abnormal expression of AURKC protein is associated with reproductive disorders and infertility in both males and females. Studies have found that AURKC gene mutations may lead to abnormal sperm or egg development and dysfunction.