Recombinant Human Aurora Kinase B

• Cat.No.: AURKB-5292H
• Product Overview: RecombinantHuman AURKB expressed in a cell expression system.

Specification

• Cat. No.: AURKB-5292H
• Description: AURKB is aprotein that functions in the attachment of the mitotic spindle to thecentromere. Chromosomal segregation during mitosis as well as meiosis isregulated by kinases and phosphatases. The Aurora kinases associate withmicrotubules during chromosome movement and segregation. AURKB localizesto microtubules near kinetochores, specifically to the specializedmicrotubules called K-fibers, and Aurora kinase A localizes to centrosomes.
• Source: Sf9 cells
• Species: Human
• Purity: Greater than 95% bySDS-PAGE.
• Form: 25 mM Tris-HCl, pH8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 3 mM DTT.
• Storage: 6 months at -80°C.
• OfficialSymbol: AURKB

Gene Information

• Gene Name: AURKB aurora kinase B [ Homosapiens ]
• Synonyms: AURKB; aurora kinaseB; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1;STK12; PPP1R48; aurkb-sv1; aurkb-sv2; aurora kinase B; ARK-2; STK-1; aurora 1;aurora-1; aurora-B; OTTHUMP00000135331; aurora kinase B-Sv1; aurora kinaseB-Sv2; aurora-related kinase 2; serine/threonine kinase 12;aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5;serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B;protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-likemidbody-associated protein 1
• Gene ID: 9212
• mRNA Refseq: NM_004217
• Protein Refseq: NP_004208
• MIM: 604970
• UniProt ID: Q96GD4
• Chromosome Location: 17p13.1
• Pathway: APC/C-mediateddegradation of cell cycle proteins; APC/C:Cdh1 mediated degradation of Cdc20and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Aurora Asignaling; Aurora B signaling; Aurora C signaling; Cell Cycle; DNAReplication; FOXM1 transcription factor network; M Phase; Mitotic M-M/G1phases; Mitotic Prometaphase; Regulation of mitotic cell cycle; Signaling byAurora kinases
• Function: ATP binding; metalion binding; nucleotide binding; protein binding; protein serine/threoninekinase activity; protein serine/threonine/tyrosine kinase activity

Reviews

12/28/2021

AURKB's exceptional repeatability allows for its reliable use in a range of applications, making it a top choice for researchers.

08/31/2021

Very pure and can be used with confidence.

02/03/2019

The quality is very high and very reliable.

Q&As

What are the interactions between AURKB protein and cell cycle regulatory proteins?

AURKB protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, INCENP, Survivin, etc., to regulate the progression of cell mitosis.

What are the intracellular substrates of AURKB protein?

The substrates of AURKB include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins. Phosphorylation modification of these substrates regulates chromosome segregation and cell division during mitosis.

What is the cellular localization of AURKB protein?

AURKB protein is mainly located in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

What is the expression pattern of AURKB gene?

The expression of the AURKB gene is regulated by cell cycle regulators and other transcription factors and is mainly expressed in the mitotic phase of cells.

How does AURKB protein activity work?

The activity of AURKB protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKB protein reach its peak expression?

The protein reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.