Recombinant Human Aurora Kinase B, GST-His
Cat.No. : | AURKB-684H |
Product Overview : | Recombinant human Aurora B kinase consisting of mino acids 2-344 was fused at the N-terminus to a GST-His Tag sequence. It was expressed inS. frugiperdainsect cells using a baculovirus expression system.MW = 70000 Da. |
- Specification
- Gene Information
- Related Products
- Download
Cat. No. : | AURKB-684H |
Description : | Aurora B is a mitotic kinase that phosphorylates histone H3 and CenpA. Upregulation of Aurora B is reported in pancreatic and prostate cancers. The active kinase is useful in the study of Aurora B regulation and for inhibitor screening. |
Source/Host : | S. frugiperda. |
Form : | Liquid. In 100 mM NaCl, 25 mM Tris-HCl, 3 mM DTT, 50% glycerol, 0.05% Tween®-20 detergent, pH 8.0. Please refer to vial label for lot-specific concentration. |
Specific Activity : | ≥12 units/µg protein. |
Purity : | ≥70% by SDS-PAGE. |
Unit Definition : | One unit is defined as the amount of enzyme that is required to phosphorylate 1 pmol Ser/Thr 1 peptide substrate per min at 30°C, pH 7.4. |
Toxicity : | Standard Handling (MSDS available upon request). |
Storage : | ≤ -70°C. Avoid freeze/thaw Following intitial thaw, aliquot and freeze (-70°C). |
Gene Name : | AURKB aurora kinase B [ Homo sapiens ] |
Synonyms : | AURKB; aurora kinase B ; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; aurkb-sv1; aurkb-sv2; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; serine/threonine kinase 12; EC 2.7.11.1; Aurora- and Ipl1-like midbody-associated protein 1; Aurora-related kinase 2; Aurora/IPL1-related kinase 2 |
Gene ID : | 9212 |
mRNA Refseq : | NM_004217 |
Protein Refseq : | NP_004208 |
MIM : | 604970 |
UniProt ID : | Q96GD4 |
Chromosome Location : | 17p13.1 |
Function : | ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
AURKB-1112H | Recombinant Human AURKB Protein (A2-A344), Tag Free | +Inquiry |
Aurkb-1789M | Recombinant Mouse Aurkb Protein, Myc/DDK-tagged | +Inquiry |
AURKB-1113H | Recombinant Human AURKB Protein (A2-A344), GST tagged | +Inquiry |
AURKB-05H | Recombinant Human AURKB (D200A) Mutant Protein, GST-tagged | +Inquiry |
Aurkb-279R | Recombinant Rat Aurkb Protein, His-tagged | +Inquiry |
◆ Lysates | ||
AURKB-8560HCL | Recombinant Human AURKB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionAURKB protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, INCENP, Survivin, etc., to regulate the progression of cell mitosis.
The substrates of AURKB include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins. Phosphorylation modification of these substrates regulates chromosome segregation and cell division during mitosis.
AURKB protein is mainly located in the nucleus and cytoplasm and participates in the regulation of cell mitosis.
The expression of the AURKB gene is regulated by cell cycle regulators and other transcription factors and is mainly expressed in the mitotic phase of cells.
The activity of AURKB protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.
The protein reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.
Customer Reviews (3)
Write a reviewAURKB's exceptional repeatability allows for its reliable use in a range of applications, making it a top choice for researchers.
Very pure and can be used with confidence.
The quality is very high and very reliable.
Ask a Question for All AURKB Products
Required fields are marked with *
My Review for All AURKB Products
Required fields are marked with *
Inquiry Basket