Recombinant Human AXIN1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | AXIN1-1983H |
Product Overview : | AXIN1 MS Standard C13 and N15-labeled recombinant protein (NP_851393) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 91.5 kDa |
AA Sequence : | MNIQEQGFPLDLGASFTEDAPRPPV PGEEGELVSTDPRPASYSFCSGKGV GIKGETSTATPRRSDLDLGYEPEGS ASPTPPYLKWAESLHSLLDDQDGIS LFRTFLKQEGCADLLDFWFACTGFR KLEPCDSNEEKRLKLARAIYRKYIL DNNGIVSRQTKPATKSFIKGCIMKQ LIDPAMFDQAQTEIQATMEENTYPS FLKSDIYLEYTRTGSESPKVCSDQS SGSGTGKGISGYLPTLNEDEEWKCD QDMDEDDGRDAAPPGRLPQKLLLET AAPRVSSSRRYSEGREFRYGSWREP VNPYYVNAGYALAPATSANDSEQQS LSSDADTLSLTDSSVDGIPPYRIRK QHRREMQESVQVNGRVPLPHIPRTY RVPKEVRVEPQKFAEELIHRLEAVQ RTREAEEKLEERLKRVRMEEEGEDG DPSSGPPGPCHKLPPAPAWHHFPPR CVDMGCAGLRDAHEENPESILDEHV QRVLRTPGRQSPGPGHRSPDSGHVA KMPVALGGAASGHGKHVPKSGAKLD AAGLHHHRHVHHHVHHSTARPKEQV EAEATRRAQSSFAWGLEPHSHGARS RGYSESVGAAPNASDGLAHSGKVGV ACKRNAKKAESGKSASTEVPGASED AEKNQKIMQWIIEGEKEISRHRRTG HGSSGTRKPQPHENSRPLSLEHPWA GPQLRTSVQPSHLFIQDPTMPPHPA PNPLTQLEEARRRLEEEEKRASRAP SKQRTRSQRKVGGGSAQPCDSIVVA YYFCGEPIPYRTLVRGRAVTLGQFK ELLTKKGSYRYYFKKVSDEFDCGVV FEEVREDEAVLPVFEEKIIGKVEKV DTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | AXIN1 axin 1 [ Homo sapiens (human) ] |
Official Symbol : | AXIN1 |
Synonyms : | AXIN1; axin 1; axin-1; PPP1R49; protein phosphatase 1; regulatory subunit 49; axis inhibitor 1; fused, mouse, homolog of; axis inhibition protein 1; protein phosphatase 1, regulatory subunit 49; AXIN; MGC52315; |
Gene ID : | 8312 |
mRNA Refseq : | NM_181050 |
Protein Refseq : | NP_851393 |
MIM : | 603816 |
UniProt ID : | O15169 |
Products Types
◆ Recombinant Protein | ||
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AXIN1-565R | Recombinant Rat AXIN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Axin1-389M | Recombinant Mouse Axin1 Protein, His-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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