Recombinant Human B4GALT7 protein, GST-tagged
Cat.No. : | B4GALT7-035H |
Product Overview : | Human B4GALT7 full-length ORF ( NP_009186.1, 1 a.a. - 327 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) linkage found in proteoglycans. Manganese is required as a cofactor. This enzyme differs from the other six beta4GalTs because it lacks the conserved beta4GalT1-beta4GalT6 Cys residues and it is located in cis-Golgi instead of trans-Golgi. Two single-nucleotide mutations were identified from a patient with the progeroid type of Ehlers-Danlos syndrome. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 63.8 kDa |
AA Sequence : | MFPSRRKAAQLPWEDGRSGLLSGGL PRKCSVFHLFVACLSLGFFSLLWLQ LSCSGDVARAVRGQGQETSGPPRAC PPEPPPEHWEEDASWGPHRLAVLVP FRERFEELLVFVPHMRRFLSRKKIR HHIYVLNQVDHFRFNRAALINVGFL ESSNSTDYIAMHDVDLLPLNEELDY GFPEAGPFHVASPELHPLYHYKTYV GGILLLSKQHYRLCNGMSNRFWGWG REDDEFYRRIKGAGLQLFRPSGITT GYKTFRHLHDPAWRKRDQKRIAAQK QEQFKVDREGGLNTVKYHVASRTAL SVGGAPCTVLNIMLDCDKTATPWCT FS |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) [ Homo sapiens ] |
Official Symbol : | B4GALT7 |
Synonyms : | B4GALT7; xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I); beta-1,4-galactosyltransferase 7; beta4Gal T7; XGALT 1; beta4Gal-T7; beta4GalT-VII; beta-1,4-GalTase 7; beta-1,4-galactosyltransferase VII; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7; XGPT1; XGALT1; |
Gene ID : | 11285 |
mRNA Refseq : | NM_007255 |
Protein Refseq : | NP_009186 |
MIM : | 604327 |
UniProt ID : | Q9UBV7 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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