Recombinant Human BIRC3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: BIRC3-2910H
• Product Overview: BIRC3 MS Standard C13 and N15-labeled recombinant protein (NP_001156) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 68.4 kDa
• AA Sequence: MNIVENSIFLSNLMKSANTFELKYD LSCELYRMSTYSTFPAGVPVSERSL ARAGFYYTGVNDKVKCFCCGLMLDN WKRGDSPTEKHKKLYPSCRFVQSLN SVNNLEATSQPTFPSSVTNSTHSLL PGTENSGYFRGSYSNSPSNPVNSRA NQDFSALMRSSYHCAMNNENARLLT FQTWPLTFLSPTDLAKAGFYYIGPG DRVACFACGGKLSNWEPKDNAMSEH LRHFPKCPFIENQLQDTSRYTVSNL SMQTHAARFKTFFNWPSSVLVNPEQ LASAGFYYVGNSDDVKCFCCDGGLR CWESGDDPWVQHAKWFPRCEYLIRI KGQEFIRQVQASYPHLLEQLLSTSD SPGDENAESSIIHFEPGEDHSEDAI MMNTPVINAAVEMGFSRSLVKQTVQ RKILATGENYRLVNDLVLDLLNAED EIREEERERATEEKESNDLLLIRKN RMALFQHLTCVIPILDSLLTAGIIN EQEHDVIKQKTQTSLQARELIDTIL VKGNIAATVFRNSLQEAEAVLYEHL FVQQDIKYIPTEDVSDLPVEEQLRR LQEERTCKVCMDKEVSIVFIPCGHL VVCKDCAPSLRKCPICRSTIKGTVR TFLSTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens (human) ]
• Official Symbol: BIRC3
• Synonyms: BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF49; TNFR2 TRAF signaling complex protein; IAP-1; IAP homolog C; RING finger protein 49; baculoviral IAP repeat-containing 3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1; AIP1; API2; CIAP2; HAIP1; HIAP1; c-IAP2
• Gene ID: 330
• mRNA Refseq: NM_001165
• Protein Refseq: NP_001156
• MIM: 601721
• UniProt ID: Q13489

Reviews

11/09/2019

Key to our research success, a trusted partner.

06/22/2017

Dependable partner, integral to research integrity.

06/12/2017

Efficient and precise, a research necessity.

Q&As

What is the primary role of BIRC3 in apoptosis regulation?

BIRC3 (cIAP2) inhibits apoptosis, regulating cell death.

How does BIRC3 interact with other proteins in apoptosis pathways?

BIRC3 interacts with proteins in apoptosis pathways, influencing cell survival.

What role does BIRC3 play in immune responses?

BIRC3 plays a role in immune response, especially in inflammation.

How do genetic variations in BIRC3 affect disease susceptibility?

Genetic changes in BIRC3 affect susceptibility to cancers and immune disorders.

How does BIRC3 contribute to cell survival?

It promotes cell survival by blocking apoptosis signals.

What is the impact of altered BIRC3 activity on inflammatory conditions?

Altered BIRC3 activity impacts inflammatory disease progression.

What potential therapeutic applications arise from targeting BIRC3 in inflammatory and cancerous diseases?

Targeting BIRC3 could treat diseases with abnormal apoptosis, like cancer and inflammation.