Recombinant Human BRCA1 Protein (BRCT domains), N-GST tagged

• Cat.No.: BRCA1-21H
• Product Overview: Recombinant Human BRCA1 Protein (BRCT domains) with N-GST tag was expressed in E. coli.

Specification

• Description: This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
• Source: E. coli
• Species: Human
• Tag: N-GST
• Molecular Mass: 53.3 kDa
• Purity: ≥90% (estimated by SDS-PAGE)
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride, and 20% glycerol
• Shipping: Dry ice in continental US; may vary elsewhere

Gene Information

• Gene Name: BRCA1 BRCA1 DNA repair associated [ Homo sapiens (human) ]
• Official Symbol: BRCA1
• Synonyms: BRCA1; BRCA1 DNA repair associated; IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53; breast cancer type 1 susceptibility protein; BRCA1/BRCA2-containing complex, subunit 1; Fanconi anemia, complementation group S; RING finger protein 53; breast and ovarian cancer susceptibility protein 1; breast cancer 1, early onset; early onset breast cancer 1; protein phosphatase 1, regulatory subunit 53; EC 2.3.2.27
• Gene ID: 672
• mRNA Refseq: NM_007300
• Protein Refseq: NP_009231
• MIM: 113705
• UniProt ID: P38398