| Description : |
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
119.5 kDa |
| AA Sequence : |
MAAVKKEGGALSEAMSLEGDEWELS KENVQPLRQGRIMSTLQGALAQESA CNNTLQQQKRAFEYEIRFYTGNDPL DVWDRYISWTEQNYPQGGKESNMST LLERAVEALQGEKRYYSDPRFLNLW LKLGRLCNEPLDMYSYLHNQGIGVS LAQFYISWAEEYEARENFRKADAIF QEGIQQKAEPLERLQSQHRQFQARV SRQTLLALEKEEEEEVFESSVPQRS TLAELKSKGKKTARAPIIRVGGALK APSQNRGLQNPFPQQMQNNSRITVF DENADEASTAELSKPTVQPWIAPPM PRAKENELQAGPWNTGRSLEHRPRG NTASLIAVPAVLPSFTPYVEETAQQ PVMTPCKIEPSINHILSTRKPGKEE GDSLQRVQSHQQASEEKKEKMMYCK EKIYAGVGEFSFEEIRAEVFRKKLK EQREAELLTSAEKRAEMQKQIEEME KKLKEIQTTQQERTGDQQEETMPTK ETTKLQIASESQKIPGMTLSSSVCQ VNCCARETSLAENIWQEQPHSKGPS VPFSIFDEFLLSEKKNKSPPADPPR VLAQRRPLAVLKTSESITSNEDVSP DVCDEFTGIEPLSEDAIITGFRNVT ICPNPEDTCDFARAARFVSTPFHEI MSLKDLPSDPERLLPEEDLDVKTSE DQQTACGTIYSQTLSIKKLSPIIED SREATHSSGFSGSSASVASTSSIKC LQIPEKLELTNETSENPTQSPWCSQ YRRQLLKSLPELSASAELCIEDRPM PKLEIEKEIELGNEDYCIKREYLIC EDYKLFWVAPRNSAELTVIKVSSQP VPWDFYINLKLKERLNEDFDHFCSC YQYQDGCIVWHQYINCFTLQDLLQH SEYITHEITVLIIYNLLTIVEMLHK AEIVHGDLSPRCLILRNRIHDPYDC NKNNQALKIVDFSYSVDLRVQLDVF TLSGFRTVQILEGQKILANCSSPYQ VDLFGIADLAHLLLFKEHLQVFWDG SFWKLSQNISELKDGELWNKFFVRI LNANDEATVSVLGELAAEMNGVFDT TFQSHLNKALWKVGKLTSPGALLFQ TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
