Recombinant Human CACYBP Protein (Ala2-Phe228), His-tagged

• Cat.No.: CACYBP-0540H
• Product Overview: Recombinant human CACYBP (Ala2-Phe228) was fused with His tag and was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 26.94 kDa
• Protein Length: Ala2-Phe228
• Purity: >90% as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CACYBP calcyclin binding protein [ Homo sapiens (human) ]
• Official Symbol: CACYBP
• Synonyms: CACYBP; calcyclin binding protein; calcyclin-binding protein; S100A6BP; SIP; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein; GIG5; PNAS-107; RP1-102G20.6; MGC87971
• Gene ID: 27101
• mRNA Refseq: NM_001007214
• Protein Refseq: NP_001007215
• MIM: 606186
• UniProt ID: Q9HB71

Reviews

11/15/2021

I saw results within weeks.

04/19/2020

Impressed with the results.

07/06/2018

High-quality product.

Q&As

How does the phosphorylation of CACYBP influence its biochemical properties and cellular functions?

Phosphorylation of CACYBP can modulate its protein-protein interactions and stability. Phosphorylation events may affect its role in cell cycle regulation and ubiquitin-dependent protein degradation.

How does CACYBP's calcium-binding capability influence its conformational dynamics and interactions with calcium-dependent proteins?

CACYBP's calcium-binding domains undergo conformational changes upon calcium binding, which can affect its interactions with other proteins. It allows CACYBP to act as a calcium-dependent scaffold for various signaling complexes.

What are the biochemical mechanisms underlying the influence of CACYBP on cell cycle progression, including its interactions with Cyclins and CDKs?

CACYBP interacts with Cyclins and CDKs, forming complexes that regulate the phosphorylation of key cell cycle regulators. These interactions affect the progression through different phases of the cell cycle.

Can you explain the role of CACYBP in ubiquitin-dependent protein degradation and its connection to the proteasome system?

CACYBP functions as an adaptor protein in ubiquitin-dependent protein degradation by facilitating the transfer of ubiquitin moieties to target proteins. It forms complexes with E3 ubiquitin ligases and substrates, directing them to the proteasome for degradation.

Can you discuss the role of CACYBP in cellular responses to stress, including oxidative stress and DNA damage, and its molecular mechanisms in these contexts?

CACYBP participates in stress responses by modulating the stability and activity of proteins involved in stress pathways. For example, it can influence the stability of DNA repair proteins and oxidative stress response factors, contributing to cellular adaptation to stress conditions.