Recombinant Human CCR4 Protein (1-360 aa), His-tagged

• Cat.No.: CCR4-2724H
• Product Overview: Recombinant Human CCR4 Protein (1-360 aa) is produced by in vitro E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal. Protein Description: Full Length.

Specification

• Description: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
• Source: E. coli Cell Free
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 44.9 kDa
• Protein length: 1-360 aa
• AA Sequence: MNPTDIADTTLDESIYSNYYLYESI PKPCTKEGIKAFGELFLPPLYSLVF VFGLLGNSVVVLVLFKYKRLRSMTD VYLLNLAISDLLFVFSLPFWGYYAA DQWVFGLGLCKMISWMYLVGFYSGI FFVMLMSIDRYLAIVHAVFSLRART LTYGVITSLATWSVAVFASLPGFLF STCYTERNHTYCKTKYSLNSTTWKV LSSLEINILGLVIPLGIMLFCYSMI IRTLQHCKNEKKNKAVKMIFAVVVL FLGFWTPYNIVLFLETLVELEVLQD CTFERYLDYAIQATETLAFVHCCLN PIIYFFLGEKFRKYILQLFKTCRGL FVLCQYCGLLQIYSADTPSSSYTQS TMDHDLHDAL
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: CCR4 chemokine (C-C motif) receptor 4 [ Homo sapiens ]
• Official Symbol: CCR4
• Synonyms: CCR4; CC CKR 4; CD194; ChemR13; CKR4; CMKBR4; k5 5; CCR-4; C-C CKR-4; K5-5; CC-CKR-4; HGCN:14099; MGC88293
• Gene ID: 1233
• mRNA Refseq: NM_005508
• Protein Refseq: NP_005499
• MIM: 604836
• UniProt ID: P51679