Recombinant Human CD22 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: CD22-158H
• Product Overview: CD22 MS Standard C13 and N15-labeled recombinant protein (NP_001762) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 95.8 kDa
• AA Sequence: MHLLGPWLLLLVLEYLAFSDSSKWV FEHPETLYAWEGACVWIPCTYRALD GDLESFILFHNPEYNKNTSKFDGTR LYESTKDGKVPSEQKRVQFLGDKNK NCTLSIHPVHLNDSGQLGLRMESKT EKWMERIHLNVSERPFPPHIQLPPE IQESQEVTLTCLLNFSCYGYPIQLQ WLLEGVPMRQAAVTSTSLTIKSVFT RSELKFSPQWSHHGKIVTCQLQDAD GKFLSNDTVQLNVKHTPKLEIKVTP SDAIVREGDSVTMTCEVSSSNPEYT TVSWLKDGTSLKKQNTFTLNLREVT KDQSGKYCCQVSNDVGPGRSEEVFL QVQYAPEPSTVQILHSPAVEGSQVE FLCMSLANPLPTNYTWYHNGKEMQG RTEEKVHIPKILPWHAGTYSCVAEN ILGTGQRGPGAELDVQYPPKKVTTV IQNPMPIREGDTVTLSCNYNSSNPS VTRYEWKPHGAWEEPSLGVLKIQNV GWDNTTIACAACNSWCSWASPVALN VQYAPRDVRVRKIKPLSEIHSGNSV SLQCDFSSSHPKEVQFFWEKNGRLL GKESQLNFDSISPEDAGSYSCWVNN SIGQTASKAWTLEVLYAPRRLRVSM SPGDQVMEGKSATLTCESDANPPVS HYTWFDWNNQSLPYHSQKLRLEPVK VQHSGAYWCQGTNSVGKGRSPLSTL TVYYSPETIGRRVAVGLGSCLAILI LAICGLKLQRRWKRTQSQQGLQENS SGQSFFVRNKKVRRAPLSEGPHSLG CYNPMMEDGISYTTLRFPEMNIPRT GDAESSEMQRPPPDCDDTVTYSALH KRQVGDYENVIPDFPEDEGIHYSEL IQFGVGERPQAQENVDYVILKHTRT RPLEQKLISEEDLAANDILDYKDDD DKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CD22 CD22 molecule [ Homo sapiens (human) ]
• Official Symbol: CD22
• Synonyms: CD22; CD22 molecule; SIGLEC-2; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; sialic acid-binding Ig-like lectin 2
• Gene ID: 933
• mRNA Refseq: NM_001771
• Protein Refseq: NP_001762
• MIM: 107266
• UniProt ID: P20273

Reviews

01/15/2021

The CD22 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

06/15/2017

Its unique properties make CD22 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.

02/17/2016

With the CD22 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

Q&As

How does CD22-targeted immunotherapy differ from traditional chemotherapy?

CD22-targeted immunotherapy is more targeted, specifically attacking cancer cells, whereas chemotherapy affects both healthy and cancerous cells.

Can CD22-targeted therapies be used in combination with other cancer treatments?

Yes, CD22-targeted therapies are often used in combination with chemotherapy or other immunotherapies for enhanced efficacy.

What other diseases involve CD22 as a therapeutic target?

CD22-targeted therapies are being explored for autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus.

Are there any clinical applications of CD22 protein in cancer therapy?

Yes, CD22 is targeted in immunotherapy for B cell malignancies like acute lymphoblastic leukemia (ALL).

What role does CD22 play in B cell function?

CD22 acts as an inhibitory receptor, regulating B cell activation and signaling.