Recombinant Human CD226 Protein, C-His-tagged
Cat.No. : | CD226-220H |
Product Overview : | Recombinant Human CD226 Protein with C-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | DNAM-1/CD226 is a member of the immunoglobulin-like superfamily. It is expressed on T cells, natural killer (NK) cells, monocytes, and macrophages. It is a major activating receptor on NK cells. Engagement with its ligands Nectin-2 (CD112) and PVR (poliovirus receptor, also known as CD155) on the target cells leads to downstream activation of ERK, AKT, and PLCg2 signaling pathways that are crucial for NK activation and NK-mediated killing. LFA-1 physically associates with DNAM-1/CD226 and contributes to its signaling. Activating signal of DNAM-1/CD226 is counterbalanced by inhibitory receptors TIGIT and CD96, competing for the common ligands CD122 and PVR. |
Source : | E. coli |
Species : | Human |
Tag : | C-His |
Molecular Mass : | ~26 kDa |
AA Sequence : | EEVLWHTSVPFAENMSLECVYPSMG ILTQVEWFKIGTQQDSIAIFSPTHG MVIRKPYAERVYFLNSTMASNNMTL FFRNASEDDVGYYSCSLYTYPQGTW QKVIQVVQSDSFEAAVPSNSHIVSE PGKNVTLTCQPQMTWPVQAVRWEKI QPRQIDLLTYCNLVHGRNFTSKFPR QIVSNCSHGRWSVIVIPDVTVSDSG LYRCYLQASAGENETFVMRLTVAEG KTDNQYTLFVA |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Concentration : | ≥0.5 mg/mL |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | CD226 CD226 molecule [ Homo sapiens (human) ] |
Official Symbol : | CD226 |
Synonyms : | CD226; CD226 molecule; PTA1; DNAM1; DNAM-1; TLiSA1; CD226 antigen; DNAX accessory molecule-1; T lineage-specific activation antigen 1 antigen; adhesion glycoprotein; platelet and T cell activation antigen 1 |
Gene ID : | 10666 |
mRNA Refseq : | NM_006566 |
Protein Refseq : | NP_006557 |
MIM : | 605397 |
UniProt ID : | Q15762 |
Products Types
◆ Recombinant Protein | ||
CD226-395H | Recombinant Human CD226 Protein (Met1-Asn247), His-Fc-tagged, Biotinylated | +Inquiry |
CD226-555R | Recombinant Rhesus Macaque CD226 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD226-658H | Recombinant Human CD226 Protein | +Inquiry |
CD226-318C | Active Recombinant Cynomolgus CD226 protein(Met1-Phe252), His-tagged | +Inquiry |
CD226-23H | Recombinant Human CD226 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
CD226-2800MCL | Recombinant Mouse CD226 cell lysate | +Inquiry |
CD226-1173RCL | Recombinant Rat CD226 cell lysate | +Inquiry |
CD226-1167CCL | Recombinant Cynomolgus CD226 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket