| Description : |
This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
46.2 kDa |
| AA Sequence : |
MFWTFKEWFWLERFWLPPTIKWSDL EDHDGLVFVKPSHLYVTIPYAFLLL IIRRVFEKFVASPLAKSFGIKETVR KVTPNTVLENFFKHSTRQPLQTDIY GLAKKCNLTERQVERWFRSRRNQER PSRLKKFQEACWRFAFYLMITVAGI AFLYDKPWLYDLWEVWNGYPKQPLL PSQYWYYILEMSFYWSLLFRLGFDV KRKDFLAHIIHHLAAISLMSFSWCA NYIRSGTLVMIVHDVADIWLESAKM FSYAGWTQTCNTLFFIFSTIFFISR LIVFPFWILYCTLILPMYHLEPFFS YIFLNLQLMILQVLHLYWGYYILKM LNRCIFMKSIQDVRSDDEDYEEEEE EEEEEATKGKEMDCLKNGLGAERHL IPNGQHGHTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
